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A subset of tumor-associated NK cells restricts checkpoint blockade sensitivity by impeding a ROR-α–dependent cytotoxic CD8 T-cell differentiation program via competition for IFNα & IL-2 Cancer Discovery Zihai Li, MD, PhD aacrjournals.org/cancerdiscover…

#ScienceSaturday ❓Why don’t some immune cells perform well in the fight against #cancer? ➡️ In this study, No-Joon Song et al. found that certain natural killer (NK) cells inside tumors can actually block the growth of the CD8+ T cells we need to fight cancer, while allowing

76 years of professorship. Wow! knoxnews.com/story/news/edu…

This is wild. Unclear mechanistically how it might happen, but this provocative study showed that cancer-associated neurons transfer mitochondria to the cancer cell to induce metabolic reprogramming and increase metastasis. Dr. G Ayala Simon Grelet nature rdcu.be/etpZ6

A win for science and humanity! !science.org/content/articl…

#LabMeeting 6/26/2025. Really proud of folks in the lab. #Passion #Purpose #Impact #CancerResearch Pelotonia Institute for Immuno-Oncology The James Pelotonia

Proximity between LAG-3 and the T cell receptor guides suppression of T cell activation and autoimmunity. cell.com/cell/fulltext/…

ICYMI: Vaccines in cancer treatment and prevention: the time is now: jci.org/articles/view/… In this viewpoint, William Becker & Kimryn Rathmell suggest that cutting‑edge mRNA neoantigen-based vaccines can train the immune system to better detect and eliminate cancer cells.

NIH announces end to funding for animal-only studies drugdiscoverytrends.com/nih-announces-…

Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy: Cell cell.com/cell/fulltext/…

Very pleased to host Mengze Lyu during his visit to Pelotonia Institute for Immuno-Oncology.

Pursue original research not citations. share.google/ZQVNXLAGzOr3iC…

Kudos to the international team from 🇨🇳 & 🇺🇸 that conducted this important study published in Cancer Cell Brain metastases are one of most dreaded complications of advanced disease. Pan-cancer human brain metastases atlas at single-cell resolution cell.com/cancer-cell/ab…

dispatch.com/story/news/hea…

Yet another layer of complexity of NK cell biology and clinical translation.

AI or not, NIH limits scientists to six applications per year science.org/content/articl…

Inspired choices recognizing excellence in immunology all around!!! Jeff Rathmell ❤️

BREAKING: We uncovered a potent immune alliance that could change how we treat solid tumors. Published in Cancer Cell , we show that Th17 cells *must* work with B cells to eliminate tumors—and keep it from coming back. 📄 cell.com/cancer-cell/fu… 🧵1/12👇Let’s walk through it:

Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures cell.com/cell/fulltext/…