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Our December issue is live – and with a great cover too! This means that it's almost time for our annual cover poll where the 12 covers from the year battle it out to see which is #chemtwitter's favourite. Dec issue here: nature.com/nchem/volumes/…

So happy to finish this complex natural product!

Here's the last semi-final in our 2021 cover poll! Covers Oct, Nov, Dec included in the next three tweets in this thread) – vote for your favourite! (Linked papers from UTSA Research, Mutschler Lab & Frances Arnold)

Today, we report an enzymatic method to prepare unsubstituted propargyl amines. Congrats to the whole team Frances Arnold Ziyang Qin Soumitra Athavale Marc Garcia-Borràs Ken Houk Zhijun Jia Arkajyoti and Ledong pubs.acs.org/doi/10.1021/ja…

Many thanks AK List for this Synfact that highlights our recent paper on enzymatic C-H amidation. Chemistry at Thieme. Frances Arnold Hirschi Lab Sharath Chandra John Hodges gao Zhen.

Found this in Bob's old inventory. Looks like a box of magic catalysts 🤩 Engle Lab

A new mechanistic take on alkene 1,2-carbosulfenylation that proceeds w/ syn-stereoselectivity. Check out the final version of #TeamNickel's study in J. Am. Chem. Soc. this week, led by Ziqi Li. bit.ly/3rx3j5t

Thrilled to share this work! We engineered a heme enzyme to activate diazirines, giving us access to donor-subsitituted carbenes in biocatalysis. Many thanks to Frances Arnold and our collaborators Emma Danelius and Tamir Gonen 🎗️. doi.org/10.26434/chemr…

Our recent work on reversing the enantioselectivity of carbene N–H insertion enzyme is now on Chemrxiv (chemrxiv.org/engage/chemrxi…)! A nice collaboration again with Marc Garcia-Borràs and Carla Calvó-Tusell. Check it out! Congrats to everyone 😀 Frances Arnold Kai Chen

We reversed the carbene NH insertion enzyme selectivity through mechanism-guided protein engineering! This work is now published on Angewante✌️onlinelibrary.wiley.com/doi/10.1002/an… Huge congrats to Marc Garcia-Borràs Carla Calvó-Tusell Kai Chen and Frances Arnold

After losing my account for over a year, I finally got it back with the help of Twitter Support👍 Here to share a review that my students and I wrote during this period on biocatalytic C–N bond-forming reactions: sciencedirect.com/science/articl…

After the Plenary Lecture by Prof. List (Ben List), 12 young scientists will give talks at wipos.org: T. Cernak, Muhammad Jbara, KatayevLab, Christine Le, H. Liao, Zhen, Neufeldt Lab, Cody Ross Pitts, Powers Lab, Courtney Roberts, Zach Wickens & C-X. Zhuo.

WIPOS 2024 (Dec 16-19, 2024 in Hawaii, wipos.org) will feature many speakers from academia: Søren Kramer, Lisbet Kvaerno, Sami Lakhdar, T. Luo, Ahmad Masarwa (Masarwa Lab), Joshua Pierce, X. Qi, Dr. Indrajeet Sharma, Sherburn Lab, Alex M. Szpilman, W. Tang, H. Xu, Andrei Yudin.

Now online: Article by Marc Garcia-Borràs, Zhen Liu & co-workers Zhen Marc Garcia-Borràs Carla Calvó-Tusell Biocatalytic desymmetrization for synthesis of chiral enones using flavoenzymes nature.com/articles/s4416… ($)

Stereospecific Enzymatic Conversion of Boronic Acids to Amines by Deirdre Hanley, Zi-Qi Li, Shilong (Gregg) Gao, Scott C. Virgil, Frances Arnold at Caltech Chemistry & Chemical Engineering, and Edwin Alfonzo in J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…

Congratulations to Professor Frances Arnold (Frances Arnold) on receiving the 2025 Priestley Medal! 🎉 The ACS is honoring Arnold, "for her pioneering contributions to the development of directed evolution as a method for chemical and biological design." cce.caltech.edu/news-and-event…

Sequence-encoded monomers, a platform for translating difunctionalization into linear polymer backbones. A fun collaboration w/ Gutekunst Group Peng Liu Group & #BMSChemistry, appearing today in Nature Synthesis. tinyurl.com/mujhve56