Our Pick of the Week, published #OpenAccess in ChemBioChem by Marc Garcia Borràs, Kai_Schuelke, Stephan Hammer and team at Bielefeld University:

'Efficient Transferase Engineering for SAM Analog Synthesis from Iodoalkanes'
ow.ly/m1te50Rinso

We are pleased to announce that #inSEIT is a >>venture>> #Finalist !
We have been ranked among the #top 10 #startup projects in the #Industrials & #Engineering category and will advance to the next round!
Let’s go @inSEITbiotech! 🔥
#innovation #biotech #industry #biocatalysis

I would like to express my gratitude to my collaborators, Marc Garcia Borràs and Prof. Yunfang Yang from Zhejiang University of Technology, for their valuable contributions to this project.

Both my group and Yang's group Yang Yang have demonstrated that nonheme iron enzymes can be engineered for enantioselective C(sp3)-F bond formation via iron-mediated radical fluorine transfer. Huge congratulations to the team led by postdoc Qun Zhao Zhao Qun , now a professor…

Efficient Access to S-Adenosylmethionine Analogs: Enzymatic alkylation of S-adenosyl-L-homocysteine using iodoalkanes chemistryviews.org/efficient-acce…

🙏 for the highlight ChemBioChem Kai_Schuelke Marc Garcia Borràs

Now online:

Article by Yunfang Yang, Marc Garcia Borràs, Xiongyi Huang-JHU Biocatalysis & co-authors

Engineering non-haem iron enzymes for enantioselective C(sp3)–F bond formation via radical fluorine transfer

nature.com/articles/s4416… ($)

Orders of magnitude higher activity, for multiple substrate, in a single enzyme engineering step?

Efficient transferase engineering for SAM analog synthesis ... towards selective alkylation with engineered enzymes Kai_Schuelke Marc Garcia Borràs #FOR5596

doi.org/10.1002/cbic.2…

#Biocatalytic strategy for the construction of sp3-rich polycyclic compounds by David Vargas, Xinkun Ren, Arkajyoti Sengupta, Ledong Zhu, Satyajit Roy, Marc Garcia Borràs, Ken Houk at UCLA Chem & Biochem, and Rudi Fasan Fasan Lab at UT Dallas Chemistry in Nature Chemistry nature.com/articles/s4155…

Excited to share our paper on stereoselective synthesis of sp3-rich molecules via enzymatic carbene transfer in Nature Chemistry!Kudos to David Vargas Xinkun Ren Arkajyoti Sengupta Ledong Zhu Satyajit Roy and great collab with Marc Garcia Borràs Ken Houk!@UTDallasChemBio shorturl.at/bfAH9

Please RT
#chemjobs #biojobs #euchemjobs #chemtwitter

Registration for NextGenBiocat, held in Heraklion (Crete), Greece on 20-21 May is open. Nextgenbiocat.org/registration

Our research unit 'Exploiting the potential of S-adenosylmethionine-dependent enzyme chemistry' #FOR5596 led by Andexer Lab will be funded by DFG public | @[email protected]. Looking forward to work with Stephan Hammer, Seebeck Lab, Lena Barra, @borras & X-less colleagues.
dfg.de/en/service/pre…

I am looking for two PhD students who are interested in using enzymes to make macrocycles. The project is a collaboration with Pedro A. Sánchez-Murcia and a nice mix of #biocatalysis , #MolecularBiology , #synthesis and #ComputationalChemistry . Interrested? See here: biocatalysis.uni-graz.at/jobs/job%20off…

A PhD position (FPI, four years) in Computational Biochemistry and Biocatalysis is open in the group of Marc Garcia-Borràs (Marc Garcia Borràs) and Ferran Feixas (@ferranfeixas) at the IQCC UdG DiMoCaT_IQCC TCBioSys Universitat de Girona #compchem

Another new #cytochromeP450 function! With #enzymes and #directedevolution , and some very clever intuition and analysis, we can push the #chemistry of the biological world into whole new and useful realms. Congrats Stephan Hammer and Marc Garcia Borràs .

Enzymes for aerobic arylalkene to ketone oxidation now in Nature Catalysis. Incl. #directedevolution , detailed mechanistic studies, carbocations, protein dynamics and application in synthesis. Great teamwork with Marc Garcia Borràs
Bielefeld University IQCC UdG CeBiTec

nature.com/articles/s4192…

Unspecific peroxygenases CAN be engineered for enantioselective conversions! 😀

Now out & open access - in ACS Catalysis fantastic work from Judith and Jordi again in collaboration with the amazing Marc Garcia Borràs GRK 2670
pubs.acs.org/doi/full/10.10…

Oral communication by Marc Garcia-Borràs from IQCC UdG at BIOChem symposium S14 - Session 4 - #BQZ2023 #Bienal2023

'Computational characterization of Biocatalytic reactive intermediates for the discovery and design of new enzymatic activities'

We have a new doctor at the IQCC! We are really pround of Carla Calvó-Tusell for completing a PhD under supervisión of Silvia Osuna and Marc Garcia Borràs. We wish her all the best in her professional future.

Escola de Doctorat de la UdG UdG Recerca Gent UdG TCBioSys