Consensus on the key characteristics of metabolism disruptors | Nature Reviews Endocrinology nature.com/articles/s4157…

Profound metabolic effects ensuing from over-expression of the GIPR in mouse adipose tissue Cell Metabolism cell.com/cell-metabolis…

By characterizing adipose tissue cell types and transcriptional programs in health and disease the authors provide a roadmap for more phenotype-tailored options in obesity treatment. Cell Metabolism cell.com/cell-metabolis…

Just in time for the holidays! Thank you ScienceNews for profiling our recent discovery of a new obesity drug target that increases energy expenditure and suppresses appetite through the same receptor! Frederike Sass NNF Center for Basic Metabolic Research (CBMR) University of Copenhagen Research sciencenews.dk/en/better-obes…

Cardiolipin deficiency disrupts CoQ-complex III interface in steatohepatitis biorxiv.org/content/10.110…

Do you have a good sense of humor, a passion for honesty, amazing interpersonal skills, curiosity, and a zest for translational science? The Drucker lab is looking for a research technician

Semaglutide and tirzepatide have revolutionised the #treatment of people with #obesity by reducing how much they eat. The next generation will need to target different mechanisms and lead to healthier and greater weight loss for more #people. Researchers have found an interesting

🚨 New paper alert! 🚨 Check out our latest work on HypoxyStat, a small-molecule therapy that increases oxygen-hemoglobin affinity and provides a practical form of hypoxia therapy. A great collaboration with Maze Therapeutics 🔗 Paper: doi.org/10.1016/j.cell… Cell

Excited to share our manuscript, where we analyzed >1,000 single muscle fibers by transcriptomics and proteomics revealing unexpected heterogeneity beyond myosin isoforms. Huge team efforts, thanks to everyone involved. Proteomics Research Infrastructure (PRI) NNF Center for Basic Metabolic Research (CBMR) nature.com/articles/s4146…

Introducing the Adipose Tissue Knowledge Portal integrating clinical and experimental results with transcriptomic and proteomic data from >6,000 women and men Cell Metabolism Karolinska Institutet cell.com/cell-metabolis…

If you missed Metabolism Day- you can catch the talks here! m.youtube.com/watch?v=oUi9JU…

Really excited for this! Lawrence Kazak, Jacqueline Beaudry, and Hoon-Ki Sung Lab put together an fantastic lineup!

VTA dopamine-releasing neurons encode palatability and control the consummatory phase of eating dependent on the specific timing of their activity, actions suppressed by activation of GLP-1R signaling during palatable food consumption #weightloss #obesity science.org/doi/10.1126/sc…

New! Online now: NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging dlvr.it/TKT483

📢 🤩Excited to share our latest paper on a #Sensory circuit that limits #Feeding before the first bite👃🧠! Huge thanks to the amazing first author @JaniceBulk and all co-authors, especially Andreas Schaefer and @tobiasackels 🙌! nature.com/articles/s4225…

A sensory circuit in mice by which the organism integrates olfactory food cues to prime satiety at the outset of a meal Nature Metabolism nature.com/articles/s4225…

As we head to the 2025 American Diabetes Association GIP biology will be part of the conversation. Here Samms and Sloop summarize the compelling scientific story of Tirzepatide and the case for GIPR co-agonism #Diabetes #Weightloss #obesity diabetesjournals.org/diabetes/artic…

Studies in rats reveal one-third of CagriSema’s #weightloss efficacy arises from an effect on energy expenditure, the blunting of metabolic adaptation, which contributes to the successful treatment of #obesity nature.com/articles/s4225… Nature Metabolism

Stay cool! biorxiv.org/content/10.110…

This is an important point! And maybe true across species. We have data from several mouse studies that challenge the widespread idea that overeating drives high-fat diet-induced obesity. See abstract "AD01.05" on page 35 in the abstracts from this year's ECO. Link👇