There are now hundreds of genes associated with autism & neurodevelopmental disorders but what key processes in brain development they each disrupt remains unknown. In an article in nature today, we start tackling this question by combining forebrain #assembloids with CRISPR

With the growing availability of spatial omics data from different techniques, CAST offers a computational tool for reconstructing single-cell multi-omic profiles and downstream analysis in a spatially resolved manner. Xiao Wang nature.com/articles/s4159…

Now online! Spatially exploring RNA biology in archival formalin-fixed paraffin-embedded tissues dlvr.it/TDrfVd

The BRAIN Initiative® Cell Atlas Network (BICAN) has launched its first major data release, marking a significant milestone in the ambitious effort to map the whole human brain. 🧵 #studyBRAIN #neuroscience #openscience

This microscope can simultaneously sequence an individual cell’s DNA and pinpoint the location of its proteins with high resolution — all without having to crack the cell open and extract its contents go.nature.com/3Y5jqGG

🪱📘 Attention science book worms :) Check out this list of Science News' favorite books of 2024, which includes Then I Am Myself the World by Christof Koch. sciencenews.org/article/best-s…

Mostly on BlåSky but excited to share James Jusuf's preprint: By integrating Micro-C with SuperRes Live-Imaging we perform absolute quantification of looping (e.g. this loop is present 3%). We quantify mESC 36k loops: <loops> are generally rare (2.3%). biorxiv.org/content/10.110…

🚀Ever wondered if there's a universal rule of spindle scaling across eukaryotes? Turns out, there is! Our study reveals an evolutionarily conserved principle driven by a surprising factor: chromosome crowding. 🧵👇short-link.me/VOGP

In the battle against brain disease, researchers can now rely on a new arsenal of genetic tools – The Armamentarium. Together with scientists from across the NIH BRAIN Initiative, we’ve created and published over 1000 new enhancer AAV vectors.

The peer-reviewed version of expansion in situ genome sequencing is now out in Science! The news is bittersweet – when we first revealed this last September, I never guessed it would be my final paper in academia, but a lot has changed. A few parting thoughts: