Congrats Alex Alex Ling 🎉🎉🎉

Big news: Revolution Medicines’ daraxonrasib received FDA fast-track review for pancreatic cancer. We are proud to collaborate with Revolution Medicines on deep correlative science in a trial involving this agent in KRAS mutant pancreatic cancer. washingtonpost.com/health/2025/11…

CRISPR live-cell imaging reveals chromatin dynamics and enhancer interactions at multiple non-repetitive loci go.nature.com/49EhzA4

Announcing our new preprint! We built SPICE, a framework that combines large-scale experiments and generative AI to design RNA sequences that control cell type-specific gene expression using alternative splicing - a powerful new modality! (1/10) Preprint: biorxiv.org/content/10.110…

BETA (nature.com/articles/nprot…) is a simple and reliable way of assigning transcription factor (TF) target genes and exploring TF function and collaborators from ChIP-seq. Thanks Ming "Tommy" Tang for reviving BETA to make it Python3 compatible and easy to run! divingintogeneticsandgenomics.com/post/reviving-…

1/ You run ChIP-seq to find where your transcription factor binds. You run RNA-seq to see which genes change expression. Now, you ask a "simple" question, what are the "direct targets"?

CycleGRN: Inferring Gene Regulatory Networks from Cyclic Flow Dynamics in Single-Cell RNA-seq biorxiv.org/content/10.110… #biorxiv_bioinfo

Aging represses oncogenic KRAS-driven lung tumorigenesis and alters tumor suppression nature.com/articles/s4358…

Online Now: Exercising through cancer: Physical activity as medicine for cancer care dlvr.it/TPJsYF

Online Now: Paneth-like transition drives resistance to dual targeting of KRAS and EGFR in colorectal cancer dlvr.it/TPK70X

Online Now: MED1-driven ecDNA super-enhancers in cancer dlvr.it/TPKJMf

Today in nature, in work led by Aditi Merchant, we report the ability to prompt Evo to generate functional de novo genes. You shall know a gene by the company it keeps! 1/n

This is real time. You can see how stable the motion is. A system placing droplets between 1 nanoliter and 1 microliter inside a 96 well plate with almost perfect repeatability. No shake. No drift. No overshoot. The robot keeps the tip on track even at this scale where tiny

Never got this type of usage/training in my PhD… lol. Someone invent automatic library prep please.🙏

Congrats! Wonderful work here!

Nature research paper: Decay of driver mutations shapes the landscape of intestinal transformation go.nature.com/3KAdDGm

📢 The Zheng Lab @HarvardMed is recruiting a Postdoctoral Fellow in organic chemistry & chemical biology to develop covalent chemistry and cancer therapeutics. 🔬 Website: sites.harvard.edu/zheng/ 📧 Contact: [email protected] Apply via 👉 academicpositions.harvard.edu/postings/15510

Register by January 19 to get the lowest rates for the AACR Conference on RAS Oncogenesis and Therapeutics (March 5-8, 2026; Los Angeles), chaired by Andrew J. Aguirre, Channing J. Der, David S. Hong, and Kevan M. Shokat. brnw.ch/21wYfix #AACRras26

Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight. I'm excited to share our new work combining genetic associations and Perturb-seq to build interpretable causal graphs, out today in nature:

AI-powered platform that screens 9,045 drug combinations with 90% fewer experiments Discovering effective drug combinations is a classic combinatorial nightmare. Every time you add a new compound, the number of possible pairs explodes, and properly mapping each pair across doses