I really enjoy reading the first preprints from new labs, esp when they are awesome. Here are 2: From Kieran Campbell Annotating single-cell proteomic data: biorxiv.org/content/10.110… From @XiaoWan38018817 Multi-scale clustering of spatial gene expression: biorxiv.org/content/10.110…

Thrilled to share our new preprint @XiaoWan38018817: in situ electro-seq that integrates soft bioelectronics, in situ sequencing, and machine learning to chart stem cell electrophysiology and gene expression at single cell resolution across time and space biorxiv.org/content/10.110…

Thanks!

Thrilled to share RIBOmap, a 3D in situ profiling method to detect mRNA translation for thousands of genes simultaneously in the context of subcellular architecture, cell types, and tissue anatomy led by Hu Zeng Jiahao Huang Rena Ren biorxiv.org/content/10.110…

Now online! Multimodal charting of molecular and functional cell states via in situ electro-sequencing dlvr.it/Smnh4f

New way to measure translation!

To fill the gap in cross-sample, cross-technology, and single-cell level spatial analyses, we created CAST to search, match, and visualize both similarities and differences of spatial molecular features across multiple samples. 1/5 Xiao Wang Michael

Excited to share SWITCH-seq, a multiplexed in situ RNA sequencing method that discerns single-base variations in rRNA. Very honored to work with Daphna Rothschild , and Theo. Thanks, Xiao Wang and Barna Lab for the incredible support and guidance.

Excited to share Deep-STARmap and Deep-RIBOmap! We enabled spatial transcriptomic and translatomic mapping of >1K genes in 200 µm thick tissue and neuron morphology co-profiling. Thanks Xiao Wang for unwavering support; Jennifer for human skin study! biorxiv.org/content/10.110…

Check this review on spatial omics!

CAST enables physical alignment of spatial omics data across replicates, techs, modalities at single-cell resolution. Such accurate alignment enables spatial atlas searching, unbiased DEG identification, and reconstruction of spatial multi-omics. DM for questions and collabs!