Xi Chen (@xichenlab) 's Twitter Profile
Xi Chen

@xichenlab

Associate Professor & CPRIT scholar @MDAndersonNews studying stress responses in tumor microenvironment and anti-tumor immunity.

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calendar_today15-09-2020 19:53:11

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Xi Chen (@xichenlab) 's Twitter Profile Photo
Xi Chen
@xichenlab

a year ago

Inhibiting IRE1 RNase in TP53-mutant TNBC allows taxane to be highly immunogenic, triggering dsRNA-ZBP1-NLRP3-GSDMD pyroptotic signaling cascade, turning PD-L1-negative cold tumors hot, and conferring these cold tumors hypersensitivity to PD-1 inhibitor.