Awesome paper alert! Learn about spectrum of chromatin condensate morphologies due to elastocapillary effects (no, liquids do not need to be spherical!), from amazing Amy Strom & Hongbo Zhao, w/ important contributions from co-authors Eeftens, Haataja, Kosmrlj.

The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: Cell cell.com/cell/fulltext/…

Heat shock proteins function as signaling molecules to mediate neuron–glia communication in C. elegans during aging: nature.com/articles/s4159…

A lysosomal surveillance response to stress extends healthspan: nature.com/articles/s4155…

Excited that our nucleolus mapping paper just came out today in Nature! Truly an amazing study from even more amazing due of Sofi Quinodoz & Lifei jiang w/ Denis LJ Lafontaine & Sebastian Klinge and other fantastic co-authors nature.com/articles/s4158…

Excited to be an investigator within the NIH SMaHT Network! nature.com/articles/s4158… nature Broad Institute Tim Coorens Eunjung Alice Lee Flora Vaccarino

Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq: Neuron cell.com/neuron/fulltex…

New Online! Degrons: defining the rules of protein degradation bit.ly/40hyN0Q

Conformational plasticity of a BiP–GRP94 chaperone complex: nature.com/articles/s4159…

We are delighted to share that Stephen Fried JHU's first work on neuroscience is now published in Science Advances. Using structural proteomics, we aim to dissect the molecular basis of cognitive decline using a rat model of cognitive aging. Short 🧵1/8 science.org/doi/10.1126/sc…

A new study from the lab Nature Medicine Over 6,000 proteins, more than 10,500 individuals. #Alzheimers, #Parkinsons, and #FTD. Muhammad Ali maps the shared and disease-specific plasma proteomic landscape of neurodegeneration WashU Medicine Neurology nature.com/articles/s4159…

Mitochondrial origins of the pressure to sleep | Nature nature.com/articles/s4158…

Why do some genetic mutations devastate specific tissues while sparing others? We explore this question in GGC repeat disorders, revealing a mechanism linking protein aggregation to tRNA splicing failure in the brain. 🧵 on our new paper in Science: 🔗 science.org/doi/10.1126/sc…

SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress: Cell cell.com/cell/fulltext/…

There are much more structural variants within our genomes than previously conceived, >26,000 per person nature.com/articles/s4158… nature.com/articles/s4158…

Diffusing protein binders to intrinsically disordered proteins: nature.com/articles/s4158…

Translational traffic jam in aging brains | Science science.org/doi/10.1126/sc…

Conventional proteomics searches struggle with many modifications and open searches may be difficult to interpret. We introduce a "detailed" mass offset search in #MSFragger boosting interpretability and localization especially in complex cases like FPOP: biorxiv.org/content/10.110…

Our follow-up work on neuronal stress and aging is now online bioRxiv! Led by postdoc @kevinrhine_, we found that double-stranded RNA activates the chronic stress response in aged neurons. Thanks to all of our collaborators at UC San Diego biorxiv.org/content/10.110…

Nature research paper: Lithium deficiency and the onset of Alzheimer’s disease go.nature.com/4mwBvbr