Excited to share my UCSD Biomed Sciences PhD Program Department of Pharmacology, UCSD PhD work from the Newton Lab just published in Biochemical Journal. Find out how a Pro can actually be a major con for #PKC #signaling portlandpress.com/biochemj/artic…

Let’s talk TRAJECTORIES A decade ago Dominic McGrosso was a junior college volunteer in my lab working with then postdoc David Gonzalez Today, DOCTOR Dominic McGrosso defended his PhD thesis in the lab of TENURED UCSD Assoc. Professor of Pharmacology and Pharmacy David Gonzalez

Dynamics of the C1A domain of #PKC on the cover of this week's Biochemical Journal - thesis work of #27 Dr. Alex Jones Alex Jones from UCSD Biomed Sciences PhD Program Department of Pharmacology, UCSD Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration bit.ly/3QYhvlx

Discover the pivotal role of a single protein kinase C mutation that switches between cancer and neurodegeneration. This research sheds light on critical pathways in disease development. doi.org/10.1042/BCJ202…

Excited to share our work on an RNA-binding protein cascade we have identified as mediator of mRNA translation to fuel #PancreaticCancer growth Salk Institute Nature Communications Department of Pharmacology, UCSD UC San Diego Health Moores Cancer Center UCSD Biomed Sciences PhD Program nature.com/articles/s4146…

Having honorably modeled, mutated, activated, translocated, dephosphorylated, ubiquitinated, degraded, and generally paid great attention to the needs of protein kinase C, as well as the entire Newton Lab, today we gave permission to PhD #27 Alex Jones to leave the lab.

Got my tea and kinase ready for ⁦UCSD Biomed Sciences PhD Program⁩ Pymol workshop today! ⁦Department of Pharmacology, UCSD⁩ ⁦Newton Lab⁩

Delighted to share our preprint identifying NRP1 as a novel co-receptor for NGF in pain: biorxiv.org/content/10.110… We show that this glycoprotein enhances NGF/TrkA signalling, where its inhibition blocks NGF-induced neuronal excitability (inc. human DRGs) and nociception. (1/2)

Great work from the Peti and Page labs on PP2A-B55 complex structures - happy to have contributed to this work. nature.com/articles/s4158…

So honored to be named an ASBMB fellow! Congrats to all the other fellows including former PAAC members Matt Gentry and Rick Page Rick Page

📢Out now, our new review: Next-Generation Genetically Encoded Fluorescent Biosensors Illuminate Cell Signaling and Metabolism by @michellefrei13 and Sohum Mehta in Annual Reviews #Biophysics annualreviews.org/doi/abs/10.114…

Dr. Andrew Lowy - UCSD Department of Pharmacology Adjunct Professor

UCSD Department of Pharmacology ranked # 1 in the Blue Ridge Institute for Medical Research Rankings! UCSD Secures Several Top Spots in Latest National Rankings for NIH Funding today.ucsd.edu/story/uc-san-d…

We preset an approach to test phosphorylation site function in high throughput. Like phenotypic CRISPR screens but instead of knocking out a gene, we mutate specific codons with base editors so the resultant protein cannot get phosphorylated that site.

Evidence suggests that Protein Kinase C Theta is involved in blood cancer. New Biochemical Journal research from the Alexandra Newton group reveals that Protein Kinase C Theta function is lost in cancer. Therapies to restore its activity in cancer are vital. doi.org/10.1042/BCJ202…

Congrats UCSD Biomed Sciences PhD Program Department of Pharmacology, UCSD grad student Stefanie Hodapp on her work showing that cancer-associated mutations in PKC theta are loss of function, regardless of whether they disrupt or enhance auto inhibition - with @Kannanlab - in Biochemical Journal portlandpress.com/biochemj/artic…

Enjoyed catching up with Nathan Shaner for our Cell Signaling San Diego Chat - he rotated with us in 2003, before joining the Tsien lab, where he created he famous colour palette of FPs.

What’s more fun than a #PKC assay with 32P and high value P81 paper? Teaching UCSD Biomed Sciences PhD Program Tiffany Kao and summer undergrad Ivo Nakefski (whose dad Eric Nalefski was a postdoc 25 years ago and did beautiful work on membrane binding kinetics of PKC).

I am participating in Alzheimer's Association Walk to End Alzheimer's for the nearly 7 million Americans living with the disease. Join my team or support me with a donation! #ENDALZ #Walk2EndAlz act.alz.org/site/TR/Walk/G…

This #chemnobel recognizes how AI is supercharging #science.