NEW PAPER Title says it all: there is no such thing as a validated prediction model doi.org/10.1186/s12916…

Congratulation to Jack Elkes for winning the judges award for best poster at the Imperial Mental Health Research Network summer event. He presented his latest research using unsupervised cluster methods to identify groups of users from engagement data in a self-guided digital mental health intervention.👏

From Belfast to Melbourne - CCR Down Under is coming The Best Critical Care Trials in the World #CCRdownunder criticalcarereviews.com/meetings/ccr-d… INTENSIVE - The Alfred ICU Chris Nickson Kirsten Bibbins-Domingo Giovanni Landoni, MD Giacomo Monti Martina Baiardo Redaelli ANZICS Clinical Trials Group Prof Carol Hodgson Paul Young

We didn't have parties to "boost morale". We didn't have quiz nights. We didn't have champagne. We watched our colleagues die. We watched the bodies pile high in their thousands. These lying, cheating, self-serving charlatans need to be flung out of office. Use your vote. Vote.

I learnt this weekend that lithium batteries can explode without even being plugged in. 😱 My sisters e-bike battery exploded & set fire to house. Lucky for firefighters fast attendance & no-one in room when it went off. Passing on as will review where I store mine from now on.

I was reminded this week of the importance of taking care when interpreting subgroup analysis in clinical trials and especially the helpful role the #ICEMAN tool can play in this regard. 1/8 #MethodologyMonday #95

TWO NEW PAPERS in The BMJ on reporting recommendations for trials with surrogate outcomes (wonderfully led by anthony Muchai Manyara and Oriana Ciani) CONSORT: bmj.com/content/386/bm… SPIRIT: bmj.com/content/386/bm… #reporting #transparency #RCT

Fantastic blog from Phastar summarising key takeaways from our 1st Contemporary Clinical Trials Meeting we hosted with ImperialCTU NIHR Research Support Service (RSS) on Group Sequential Designs, Response Adaptive Randomisation & Sample Size re-estimation #CCTMM24

The 6th major trial result at #CCRdownunder is SCREEN ➡️electronic early notification of sepsis in hospitalized ward patients 🔴Alert system based on the electronic medical record qSOFA score 🔴stepped-wedge cluster RCT 🔴calculated n=65,250 Presenter - Yaseen Arabi

Here in London - we have zero-tolerance for racism, Islamophobia, antisemitism or any form of hate and we pride ourselves on being open, diverse and welcoming of all faiths and backgrounds. Those who seek to divide our communities will never win.

A couple of years ago I thought it might be fun to start the week with a tweet about some aspect of trial, or related, methodology - tagged #MethodologyMonday. 100 topics later, I hope you have found some of them useful. Here is a list of the topics so far 1/2

New Job Opp as NIHR RSS National Scientific Coordinator. To support establishment of the NIHR RSS Methods Academy & undertake national coordination of methods activities across all 8 RSS hubs. Very exited for this! All info in link 👇 . RT's appreciated rb.gy/y8as3u

Pleased to share that R2 of the NIHR Undergraduate Internship Programme is launching on 10th September 2024! nihr.ac.uk/funding/nihr-u… Slight changes this round so if you're thinking of applying, please do read the guidance notes carefully once online. Closes: 7th November 2024

To ensure the wider research community can benefit from our novel methodological approaches, we develop freely available code to use in #Stata and #R. Find a list of our available software packages on our website👇 mrcctu.ucl.ac.uk/our-research/m…

Paper #7 in our BMC Trials special series looks at public opinion on terminology used to describe #AdverseEvents & how these outcomes are communicated in the scientific literature & public facing material on medications. rdcu.be/dSwEa

We found some surprising results ⬇️ 1. Whilst researchers have sought an agreement for a term for monitoring the potential harmful effects of interventions, public partners endorse the use of different terms for different situations.

2. Contrary to the recent CONSORT Harms update our public partners preferred the use of ‘side‑effect’ and thought it was an appropriate term to use across all contexts and the use of ‘harm’ should be used to indicate more severe events. bmj.com/content/381/bm…

That's a wrap on our National Institute for Health and Care Research NIHR Research Support Service (RSS) internships! It's been a delight to host enthusiastic, engaged undergrads ImperialCTU. We hope they've learnt lots about clinical trials & what a research career looks like. We're excited to see what the future holds for them all 🌟