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Out in Immunity today! My preview of a recent study from Zhu and colleagues (cell.com/immunity/fullt…) identifying Nur77 as a cytosolic sensor of LPS and mitochondrial DNA involved in NLRP3 activation. authors.elsevier.com/a/1guwb3qNrUu3…

Love this #notthecover from Pukkila-Worley Lab is also @rpwlab.bsky.social MD/PhD student Sammy Tse! The study it depicts is pretty fabulous as well.

Taking a break on the last day of #KSinnateimmune23 to get some runs in Snowbird!

Congratulations to Orzalli lab graduate students Jenny and Jafira for passing their Qualifying Exams! Excited to see where their projects take them over the next couple of years.

On my way to DC for #AAI2023. Looking forward to sharing our work on inflammasomes in cutaneous antiviral defense tomorrow during Major Symposium B. Come say hi!

Congratulations, Andrea!!!! Reboldi Lab

Thank you to the Icahn School of Medicine at Mount Sinai Department of Microbiology for hosting me today for a visit/seminar. Had a great time sharing our work and getting to talk science with the faculty and trainees!

Love coming into the lab and seeing so many plaque assays!

On my way to #IHW2023...but likely going to get stuck in SLC tonight after a 3 hr delay on the tarmac in BOS. Hopefully won't miss too much of the Satellite sessions tomorrow.

Herpetic Legion #IHW2023

Hanging out with the lab at a WooSox game!

Accurate

Congratulations to Jafira and our other IITP trainees!

Honored to have been selected for this award. It has been a true joy mentoring the students in my lab as they pursue their PhD studies!

The Orzalli lab’s first paper is out today Journal of Experimental Medicine! See the excellent tutorial from first author Pooja Parameswaran below.

Hot damn!!!

Congratulations to Orzalli Lab MD/PhD student Jenny Powers on her outstanding F30 score! If paylines stay the same in FY25 (fingers crossed) her grant will likely be funded! UMass Chan Program in Innate Immunity

Our August issue is out! hubs.la/Q02JTSw30. The cover shows HSV-1 infection inhibiting ASC speck formation in an A549 cell line. ASC-GFP is in green, ICP0 from HSV-1 is in red, & cell nuclei are in blue. From Pooja Parameswaran Megan Orzalli et al. hubs.la/Q02JTy5C0

SARM - an enzymatic TIR protein. Perhaps the most ancient immune regulator in the Tree of Life and the origins of innate immunity itself. But, is it an immune sensor in animals?

UMass Chan Medical School seeks the next generation of scientific leaders! Join our research community as a UMass Chan Early Independence Fellow. Get 3-5 years of support. Apply by Dec 1: academicjobsonline.org/ajo/jobs/28425 UMass Chan Medical School RNA Therapeutics Institute