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CAR T cell combination therapies to treat cancer dlvr.it/TBwmGl

Thrilled to announce that my back-to-back co-first author papers are out today in nature! We present a long-term clinical study in patients and a preclinical study in mice, demonstrating the unexpected role of type-2 immunity in sustaining durable CAR T and ICB immunotherapies!

Tremendously proud to share my fellowship work, online today in Nature Medicine. We tried to understand why CAR T therapy for AML doesn't work as well as we hoped it would, and how we can solve that. 👇🧵1/10 Penn Medicine CHOP Research Saar Gill nature.com/articles/s4159…

#Glioblastoma (GBM) is a devastating disease. But hope may be on the horizon. #CARTcelltherapy trailblazer Carl June shares how the revolutionary therapy has showed promise in recent trials involving #GBM patients.

Published today Nature Biotechnology: @CarlHJune and I reveal how CAR T cells are finally tackling solid tumors! Penn Postdoctoral Association Penn Medicine MD nature.com/articles/s4158…

Engineered T cells (CAR T) have had marked success in liquid cancers (such as leukemia, lymphoma) but have had a tougher time with solid cancers. Here’s a brilliant perspective by leaders of the field for how this can be accomplished

CAR-T cells are my favorite topic in immune cell engineering and my primary research focus. It’s about training the special forces of the immune system to wipe out cancer! Very nice review by Uğur Uslu and Carl June who pioneered CAR-T cell therapy Ugur Uslu 💯

Beyond the blood: expanding CAR T cell therapy to solid tumors - Ugur Uslu Carl June go.nature.com/3Z4eBiQ

NEW! Beyond the blood: expanding CAR T cell therapy to solid tumors Nature Biotechnology Ugur Uslu Carl June nature.com/articles/s4158…

Ugur Uslu Carl June Penn Medicine CAR T cell therapy breakthroughs bring new hope for treating solid tumors #NBTintheNews news-medical.net/news/20241113/…

Look beyond blood. 🩸 Read about Drs. Ugur Uslu and @CarlHJune's perspective on expanding CAR-T cells to solid tumors in Nature Biotechnology. go.nature.com/4hROdjj

CAR T cell #immunotherapy in autoimmune disease- the origin story and current status Science Magazine science.org/content/articl…

Grateful to be named a 2024 RISE Scholar by Parker Institute for Cancer Immunotherapy, alongside this incredible group of researchers driving advancements in cancer immunotherapy. Honored to be part of this effort toward a future where all cancers are curable!

CAR T cells have cured cancer for many patients. But the current treatment process is a laborious (and expensive) one. That's why Carl June teamed up with The Drew Weissman Lab to explore using #mRNAvaccines to help a patient's own body create the #CARTcells needed to fight cancer.

IL-9 signaling redirects CAR T cell fate toward CD8+ memory and CD4+ cycling states, enhancing anti-tumor efficacy doi.org/10.1101/2025.0… Carl June Sofía Castelli

Excited to share my PhD thesis work with @CarlHJune now out as a preprint on bioRxiv! We show that engineering IL-9 signaling enhances CAR T cell antitumor efficacy by steering them toward potent memory and effector states. biorxiv.org/content/10.110…

The April issue is live, with a focus on cancer immunotherapy nature.com/nbt/volumes/43… On the cover, recent clinical trials and patient reports have found promising outcomes of locoregional administration of CAR T cells across different solid tumors go.nature.com/3Z4eBiQ

Treating the untreatable - "Enhanced CAR T-Cell Therapy for Lymphoma after Previous Failure" Penn Medicine @nejm #immunotherapy nejm.org/doi/full/10.10…