Here UC San Francisco, we have developed a new rating scale to examine the effects of 3 different drugs: psilocybin containing mushrooms, ketamine and MDMA. If you have 3+ prior experiences with each of these, please help us by completing this short survey: ucsf.co1.qualtrics.com/jfe/form/SV_a3…

Causal functional maps of brain rhythms in working memory pnas.org/doi/abs/10.107… #neuroscience

compasspathways.com/compass-pathwa…

What is jhana? Announcing our new paper in Mindfulness (@springernature): “Toward a Unified Account of Advanced Concentrative Absorption Meditation. A Systematic Definition and Classification of Jhāna” We present the most comprehensive review of advanced concentrative ... 🧵

Evidence for a possible "entourage effect" in Psilocybe mushrooms? A brand new paper studied the four main tryptamines found in Psilocybe mushrooms (as well as their "active" dephosphorylated forms) with the aim of characterising their chemical and biological effects... It's

Today I want to highlight the work of one of my absolute most favorite psychedelic artists: Symmetric Vision (aka. StingrayZ) Symmetric Vision He is the person who kick-started r/replications, which is the largest and most advanced community of psychedelic replications where

/1 Ever wondered how #psychedelic effects change across the human lifespan? We explored this question in two observational studies published last month in Am Jnl of Geriatric Psych & Frontiers: N=106 Older adults ≥60y sciencedirect.com/science/articl… N=435 Adolescents <25y frontiersin.org/articles/10.33…

Nature Brain-reading device is best yet at decoding ‘internal speech’ nature.com/articles/d4158…

After a high dose of psilocybin, the brain desynchronizes at a massive scale, causing loss of our sense of self, time, and space. This may drive the burst of plasticity caused by psychedelics. The next day, brain activity has largely returned to normal, but an echo remains – a

The principle that 5-MeO-DMT has no appreciable action at 5-HT2AR accounting for its 'psychedelic' effects has troubled me. Is there a case that it's metabolite, bufotenine, accounts for an appreciable amount of its action? See its 2A Ki in pink below.

vox.com/future-perfect… The FDA just announced with their vote today that it’s safer to live with PTSD than to receive MDMA-Assisted Therapy from a trained provider. What do you think of that? Tim Ferriss Rick Doblin, Ph.D., of MAPS Matthew W. Johnson Jon Lubecky Lauren Taus

This blogpost from 2017 by Earthly Covenant יהוה ⇢ ב׳ליה ו ב׳לה, changed everything for me as a teen. Smoothed out the existential crises I’d had for years and has led me toward so many beautiful ideas and experiences. Thank you for writing this 😎 earthlycovenant.com/beyond-religio…

The neural geometrodynamics framework of psychedelics. 🧵1/10

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Announcing our new study of dynamics of natural brain modes and relations to phenomenology during jhana advanced meditation Delighted to share our new paper in Cerebral Cortex entitled: “Investigating the complex cortical dynamics of an advanced concentrative absorption

🧵 THREAD: A federal whistleblower just dropped one of the most disturbing cybersecurity disclosures I’ve ever read. He's saying DOGE came in, data went out, and Russians started attempting logins with new valid DOGE passwords Media's coverage wasn't detailed enough so I dug

You haven’t seen psychedelic visuals / experiences explained like this before... Recently I was invited to MIT for their Augmentation Lab event, and their final event was a live conversation on psychedelics and DMT (5‑MeO) with Andres Gómez Emilsson Captain Pleasure, Andrés Gómez Emilsson. Here’s early

For thousands of years, Theravāda Buddhism—an ancient tradition with origins in India—has described what is considered the highest meditative attainment, called nirodha samāpatti, regarded as deeply connected to nirvana/enlightenment. For the first time, we have been able to use

I’ll share a small part of pickle.com Back in med school, I became obsessed with augmenting memory and dreamed of a Notion or Obsidian that completes itself. Today, we’ve built something close. My self-awareness is sharper and everything feels connected. I