Mechanical forces induce drug resistance in PDAC. Targeting the underlying mechanisms can improve therapeutic outcomes. Research supported by European Research Council (ERC) nature.com/articles/s4200…

Inhibiting autophagy with hydroxychloroquine improves oxaliplatin efficacy in pancreatic tumors, when combined with losartan. This increases oxaliplatin potency & improves blood vessel integrity. Cancer Biophysics Lab, Triantafyllos Stylianopoulos nature.com/articles/s4200…

Mathematical modelling of tumor growth, angiogenesis and immune response utilizing discrete and continuous modelling approaches. Research supported by European Research Council (ERC) nature.com/articles/s4434…

PostDoc Position in Microenvironment and Cancer BioEngineering. Info & apply here: zervalab.com/join-the-team Please RT. UPMC Hillman Cancer Center University of Pittsburgh Pitt Bioengineering UPMC

From the teams of Hadi T. Nia, Rakesh Jain and Lance Munn, this Review defines the four physical hallmarks of cancers and discusses the methods and technologies for assessing each hallmark. nature.com/articles/s4159…

Use of math modeling and AI can improve delivery and efficacy of cancer therapies. New article of our Cancer Biophysics Lab at University of Cyprus in collaboration with Edwin L. Steele Laboratories , Harvard Medical School published in Nature Reviews Cancer nature.com/articles/s4156…

#REVIEW 🚨 Triantafyllos Stylianopoulos & Rakesh Jain & Co review the utility of continuous models & discrete models in therapy delivery and efficacy in cancer and propose ways to integrate mechanistic and AI-based models to improve patient outcomes. 📖 👇 bit.ly/3X7JGAu

new article from our Cancer Biophysics Lab on the mechano-pathology of solid tumors! frontiersin.org/journals/cell-…

Exciting news! My European Research Council (ERC) Advanced grant started today, at the same time that we are moving to our new buildings of the UCY Faculty of Engineering , which will bring our Cancer Biophysics Lab to the main campus of the University. cordis.europa.eu/project/id/101…

Bone marrow vessels are hyperpermeable to macromolecules and nanoscale medicine in a size-dependent manner. | Kazunori Kataoka, Kawasaki Institute of Industrial Promotion | [Open Access] #TransvascularTransport #intravital #microscopy kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2…

Normalization strategies can lead to complete cure in murine breast tumor models. New article of our Cancer Biophysics Lab in J Cornelius Sonopermeation combined with stroma normalization enables complete cur... sciencedirect.com/science/articl…

Sonopermeation combined with stroma normalization enables complete cure using nano-immunotherapy in murine breast tumors. | Fotios Mpekris University of Cyprus | [Open Access] #sonopermeation #mechanotherapeutics #MachineLearning kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2…

How can AI and math modeling transform cancer therapy? Our latest review Nature Reviews Cancer explores how mechanistic models and machine learning can optimize drug delivery and efficacy in tumors by integrating biology, physics, and patient data. nature.com/articles/s4156… #AI #Cancer

Honored to celebrate Dr. Rakesh Jain’s inspiring AACR 2025 Lifetime Achievement Award! 🏅 His keynote on “Normalizing the Tumor Microenvironment” was a masterclass in translational science. A proud moment for Edwin L. Steele Laboratories and Mass General Cancer Center! AACR #AACR25 Ludwig Cancer

Dr. Rakesh Jain @SteeleLabsMGH shared insights from his decades-long work on vascular normalization—from concept to clinic. His lecture emphasized strategies to improve tumor vessel function and how these principles are transforming cancer therapy at #AACR25 Harvard Medical School

New publication Alert! We developed a mathematical model to decipher how the gut microbiome shapes cancer immunotherapy response. Microbiome composition influences immune cell activation & killing rates—critical for tumor control. doi.org/10.1158/0008-5…

Mathematical Modeling and Association Analysis Deciphers the Impact of the Gut Microbiome on Cancer Immunotherapy A new study from Edwin L. Steele Laboratories , Cancer Biophysics Lab and MD Anderson Cancer Center , University of Cyprus, Harvard Medical School with lancemunn, Rakesh K Jain, Jen Wargo! aacrjournals.org/cancerres/arti…

new article from our Cancer Biophysics Lab in collaboration with Fotos Mpekris and Cyprus Institute of Neurology and Genetics!

New in the August 15 issue from the Cancer Research special series: #MathematicalModeling and Association Analysis Decipher the Impact of the #GutMicrobiome on #CancerImmunotherapy brnw.ch/21wV1Wc Triantafyllos Stylianopoulos University of Cyprus Edwin L. Steele Laboratories MD Anderson Cancer Center #OpenAccess

Our latest work on 🫁 drug delivery is now published as open access in Nature Scientific Reports: A 3D computational model of the airway surface liquid (ASL) that resolves cilia motion and viscoelastic mucus to track dissolution and transport of small‑molecule drugs. The work