🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

New Resource online now! A single-cell atlas of chromatin accessibility in the human genome 🧬🧬 #sciencetwitter #chromatin #singlecell bit.ly/3D6bhGp

Seven technologies set to shake up science in 2022 go.nature.com/3FZBC9P

For those interested in high-resolution targeted Chromosome Conformation Capture (3C), we have published a comprehensive step-by-step protocol of the Capture-C approaches: nature.com/articles/s4159…

New! Tessadori et al. demonstrate that de novo variants in histone H4 cause a neurodevelopmental disorder bit.ly/3IgnevO

Today is #RareDiseaseDay, a day dedicated to raising awareness and generating change for the 300 million people living worldwide with a #RareDisease. To mark this day, here is a selection of recent content on #RareDiseases we published Nature Medicine rarediseaseday.org

Excited to share our new preprint on how DNA supercoiling influences eukaryotic gene expression. Using live-cell transcription imaging, we show that DNA torsional stress generated during transcription can inhibit the expression of neighboring genes. biorxiv.org/cgi/content/sh…

Best to choose chromatin accessibility over histone modification-based chromatin states to capture the regulatory landscape of cells. "Chromatin accessibility does not depend on transcription". nature.com/articles/s4158…

Really excited to share our latest paper... fantastic collaboration with Marieke Oudelaar where we developed tiled Micro Capture-C to generate Hi-C like plots at 20bp resolution. Turns out there are nanoscale TADs inside enhancers! nature.com/articles/s4146…

MCM complexes are barriers that restrict cohesin-mediated loop extrusion | Nature nature.com/articles/s4158…

Our 2023 Genetics Society Medal goes to Prof Douglas Higgs for his major contribution to the understanding of how mammalian genes are switched on and off during lineage specification and differentiation using haematopoiesis as a model. genetics.org.uk/medals-and-pri… MRC WIMM

Understanding telomere biology in childrens & TYA cancer — our latest paper is published as an NAR Breakthrough article! MRC WIMM Department of Paediatrics RDM Oxford OxfordOncology Oxford Cancer University of Oxford

ATR-X syndrome was first described in the 1990s by Prof. Richard Gibbons & MRC WIMM's Doug Higgs: read about how identifying the gene & an early diagnosis has helped Noah and his family:

Exciting news!🎉Just released our manuscript on #BioRxiv! Grateful to the amazing team Michela Guanlin Wang 王冠琳 and collaborators who made this possible! And thanks very much for my supervisors Beth Psaila Adam Mead, and big support from professor Tao Dong!

It's out. All in the title. If interested in an updated overview of gene regulation from an 'enhancer cluster' perspective, check it out. MRC WIMM University of Oxford Gene Regulation CTCF Papers 📚 Cell Nature Genetics Hughes Group Nucleic Acids Res onlinelibrary.wiley.com/doi/10.1002/bi…

Come join us! We are recruiting an RA to support our work understanding blood cancer development and testing new therapies. Great opportunity to learn tissue culture, organoids, cancer biology with Abdullah Khan and Adam Mead. See Job ID: 169105 at jobs.ox.ac.uk/home

Heading home from #ASH23? 👩‍💼🌞🌮Stuck in a line at security or facing a long layover? ✈️In withdrawal from all the amazing science? 🧪🧬 Read our preprint from my PhD work University of Oxford MRC WIMM presented in the MPN session yesterday! bit.ly/47RS2jg 1/n

NEW: Researchers from the Laboratory of Gene Regulation, led by Mira Kassouf & Doug Higgs, have identified a new type of non-coding DNA that helps to explain how our DNA is read. 👓🧬 Published today in Cell (Cell)! Read the full story here: bit.ly/3uQvb91

Morning everyone! Pleased to share a detailed protocol of our bone marrow organoid approach in Nature Protocols : nature.com/articles/s4159….

Excited to share our latest multi-niche bone marrow organoid model! Feeling privileged to have had the chance to work on this with an amazing team!

we are recruiting!! Ads live for 2 research assistants/biobankers and a data coordinator - working on a new Ludwig Cancer - MRC WIMM joint initiative to prevent progression from early to advanced blood cancer. Joint appointment between my lab and Adam Mead. Links below!