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A Review on #microglia heterogeneity, modeling and cell-state annotation in development and neurodegeneration nature.com/articles/s4159…

The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour nature nature.com/articles/s4158…

PTP1B inhibition promotes microglial phagocytosis in Alzheimer's disease models by enhancing SYK signaling biorxiv.org/content/10.110…

Identification of the velum interpositum as a meningeal-CNS route for myeloid cell trafficking into the brain: Neuron cell.com/neuron/fulltex…

How are big proteins washed out from CSF, if they can’t go through the glymphatic system? Here is how: our new finding on glymphatic bypass || nature.com/articles/s4159… Congrats Antoine and Ben Plog and thank you to our many collaborators!

Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain nature.com/articles/s4159… Nature Neuroscience

I wrote a review of a recent paper on false discovery and multiple testing correction. liorpachter.wordpress.com/2025/06/16/rep…

Nerve-associated portal macrophages function to maintain liver immune homeostasis nature.com/articles/s4159…

Epigenetic reprogramming as a strategy for treating neurodegeneration 🧠 tinyurl.com/ys4eh9yw

Our latest paper, Identification of conserved and tissue-restricted transcriptional profiles for lipid associated macrophages, is online at Communications Biology. UMN Integrative Biology & Physiology Ivanov lab Xavier Revelo rdcu.be/esUdT

Thrilled to share our study Immunity how a TB-vaccine (BCG) and a fungi fragment (b-glucan) synergistically train neutrophils against cancers A big shout out to Leonardo Jurado the entire team and collaborators Josefowicz Lab Ajitha Thanabalasuriar Eva Kaufmann authors.elsevier.com/a/1lJal_OR%7Ey…

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway: Immunity cell.com/immunity/fullt…

Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia nature.com/articles/s4159…

Our new study by Siling Du reveals how CSF1R mutations in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) disrupt glial homeostasis. Key roles for oligodendrocytes, astrocytes & STAT3 signaling. nature.com/articles/s4159…

Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus | Science Translational Medicine science.org/doi/10.1126/sc…

Online now: Diet-derived LPS determines intestinal IgA induction and repertoire characteristics independently of the microbiota dlvr.it/TLZYbj

Online now: Optogenetic vagal nerve stimulation attenuates heart failure by limiting the generation f monocyte-derived inflammatory CCRL2+ macrophages dlvr.it/TLbc9J

Online now: More TOR: The expanding role of mTOR in regulating immune responses dlvr.it/TLfByQ

Hello RNA World! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in Cell Reports, Faraz K Mardakheh and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit! tinyurl.com/ydn6e3ac

The real challenge abroad? Not what we say—but how we say it across cultures. Why does negotiation still feel hard? I share this (very brief!) personal reflection in Science Magazine #nextgensci feature. Grateful to Jennifer Sills and team !