📢 Exciting news! Rfam 15.0, our latest major release, is here! 🎉 You can follow our blog post to learn more about xfam.wordpress.com/2024/09/30/rfa…. Spread the news with your fellow RNA researchers. #RNA #noncodingRNA

R2DT 2.0 is now live! 🎉 This major update introduces exciting new features for RNA secondary structure visualisation, making it easier than ever to explore RNA structures. Learn more in our new preprint: biorxiv.org/content/10.110… #RNA #RNAstructure #bioinformatics

Ever wonder what happens when you delete tRNAs in E. coli? Then check out our paper where we systematically deleted each of the tRNA transcriptional units. nature.com/articles/s4159… Congratulations Sanja! Scientific Reports

Perfect timing! our latest paper on #tRNA engineering is now published, coinciding with the ongoing #tRNA2024 conference. This publication is the result of a phenomenal team effort with Jeffery Tharp academic.oup.com/nar/article/do…

Our paper on 🦠queuosine 34 modification of tRNA tyrosine and antibiotic response is finally out in its final form in eLife - the journal ... and quite different from the preprint version. Many thanks to reviewers, editors and kudos to all authors🙏 elifesciences.org/articles/96317

The tRNA m1A modification as a metabolic checkpoint of cholesterol biosynthesis to enhance the tumor-killing capacity of CD8+ T cells Journal of Experimental Medicine doi.org/10.1084/jem.20…

Congratulations to the Fu Lab Dragony Fu. It is great to be part of this #tRNA study.

Learn about how tRNA variants lead to mistranslation from O'Donoghue's Lab. It's another great collaboration that our lab leveraged the advantages of OTTR-seq in #tRNA studies. Mistranslating the genetic code with leucine in yeast and mammalian cells tandfonline.com/doi/full/10.10…

Not all tRNA fragments (tDRs) are created equal. Here we share methods to differentiate: 1) bone fide tDRs and those produced by dissociation of nicked tRNAs, 2) nicked tRNAs / tDRs in extracellular vesicles vs outside. 1) sciencedirect.com/science/articl… 2) sciencedirect.com/science/articl…

Check out the new R2DT 2.0 paper and try it out r2dt.bio It is great to be part of this project.

#NewPaper 🧬 A new review dives into the structural biology of tRNA modifying enzymes. Authored by our scientists led by Sebastian Glatt highlighting how cryoEM & crystallography reveal mechanisms behind key modifications. Read here: shorturl.at/akpeB Uniwersytet Jagielloński

I’m happy to share our recent manuscript in which we are structurally and biochemically investigating 3'-5' tRNA splicing ligases, including a #cryoEM structure of the five-subunit D. rerio tRNA ligase complex. jbc.org/article/S0021-…

We are very excited about our latest work, which just came out The EMBO Journal – embopress.org/doi/full/10.10…. The work Malopolska Centre of Biotechnology UJ was driven by Anna Biela and Ting-Yu Lin in collaboration with Janusz Bujnicki and his team IIMCB, Warsaw, Poland…a short🧵

🚨 EMBL-EBI is hiring a Project Leader to shape the future of RNA resources! Lead RNAcentral & Rfam, collaborate with global experts, and drive innovation in RNA biology. Apply now: embl.wd103.myworkdayjobs.com/en-US/EMBL/job… 🚀 #RNA #Bioinformatics #Genomics #DataScience #LifeSciences #EMBL

journals.asm.org/doi/10.1128/mb… First big Tucker lab paper! Everyone in the lab made an appearance on the author list:) So proud and grateful for our collaborators and to the editors/reviewers for helping us improve the manuscript.

RNase L cleaves most tRNAs in the anticodon loops into various tRNA-derived RNAs (tDRs) including 5'-tDRAla that shows a translation inhibitory effect. Some tRNAs are also cleaved in variable loops. bit.ly/3YTwlNq

Our Science Magazine paper is out! Discovered how tRNA-derived small RNA (tsRNA/tDR) protects kidneys via RNA autophagy. science.org/doi/10.1126/sc… Huge thanks to Saumya Das and all our amazing collaborators! Excited for the therapeutic potential ahead! Mass General Anesthesia MGH Cardiovascular Research Center

tRNA hydroxylation is an epitranscriptomic modulator of metabolic states affecting Pseudomonas aeruginosa pathogenicity, with TrhPO, from Haussler lab academic.oup.com/nar/article/53…

tRNA modification profiling reveals epitranscriptome regulatory networks in Pseudomonas aeruginosa 🦠👏High-throughput tRNA epitranscriptome profiling using mass spec on P. aeruginosa transposon insertion library and links with metabolic networks doi.org/10.1093/nar/gk…