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We are excited to announce the next speaker for MitoTalks Down Under- Alexey Amunts https://bsky.app/profile/amunts.bsky Assoc. Prof. Alexey Amunts! Join us for a Mitoribosome Odyssey on the 29th of April at 4pm AEST. Register here: forms.gle/1U4G9HPHnbmDQb… Zoom details to follow soon!

Very happy to see our paper "Optic Atrophy-associated TMEM126A as an assembly factor for the ND4-module of Mitochondrial Complex" now out in PNAS. Thanks to lead Luke Formosa plus BorisReljić Alice Sharpe @daniellahock Linden Muellner-Wong Stroud lab (account no longer in use) pnas.org/content/118/17…

This Sunday we are teaming up with @DrDStojanovski lab to form the Bio21 Institute Blazers and walking 35km in the The Bloody Long Walk to raise funds for #mitochondrialdisease. Check out this video I made with @daniellahock and the legend Noah about how the walk supports our work 👇

Stojanovski &co @DrDStojanovski Bio21 Institute University of Melbourne use STORM to visualise the distribution of mitochondrial complexes at the nanoscale; more in our free Research highlight: ow.ly/k2bB50FEvvp

Looking forward to hearing all about some amazing mitochondrial biology!!

Many of us have done sodium carbonate extractions to determine the membrane association of a single protein, but have you done it on >840 mitochondrial proteins at the same time, across two pH and multiple KO cell lines? Check out our new paper on SCE-MS: frontiersin.org/article/10.338…

So excited to see Jessica Spinelli present next week! It is sure to be some beautiful and elegant #biochemistry for #mito enthusiasts!

Great work from the big man Kenji Fujihara and Clemons Lab. Excellent study showing that eprenetapopt can induce ferroptosis. Great to watch the project develop over the years, and happy to have had the opportunity to be involved.

WE'RE HIRING! ☀️ Clemons Lab Peter Mac Research is expanding and looking for a talented postdoc or research assistant to help investigate immunotherapies in gastro-oesophageal cancers. If you have 🐁 experience and interest in cancer biology, join our team! Details/apply 👇 Please RT!

Our latest paper published now in Nature Communications: Epigenetic suppression of PGC1α can sensitize BRAFi-resistant melanomas to HMGCR inhibitors, check it out! nature.com/articles/s4146… Dana-Farber Cancer Biology Department @HarvardCellBio Gygi Lab Brigham and Women’s Dermatology

New area of study from our research program on mitochondrial biology; “Selective Mitochondrial Respiratory Complex I Subunit Deficiency Causes Tumor Immunogenicity”, including sensitization to immune checkpoint blockade; pre-print at bioRxiv; biorxiv.org/content/10.110…

New studies from Puigserver Lab at Dana-Farber Cancer Biology Department @HarvardCellBio finding Mitoribosome Quality Control as protective mechanism against pathogenic human mitochondrial disease mutations, published EMBO Reports embopress.org/doi/full/10.15…

Excited to share our latest preprint by postdoc Pedro Latorre Muro in collaboration with Vivek Sharma and #LiaoLab. We combined #physiology and #cryoem to determine respiratory supercomplex adaptation in brown adipocytes in response to cold environments: biorxiv.org/content/10.110…

Amazing to see our work on the mitochondrial CLPB disaggregase finally published in Journal of Cell Biology! Thank you @DrDStojanovski and UniMelb MDHS for all your support! CLPB disaggregase dysfunction impacts the functional integrity of the proteolytic SPY complex rupress.org/jcb/article-ab…

New paper by Pedro Latorre Muro published in Cell! We combined thermoregulatory physiology, structural and computational approaches to determine the mechanisms of electron transfer and structural basis of respiratory complex adaptation to cold temperatures.

New article by Pedro Latorre Muro published in Nature Cell Biology Molecular mechanisms of ER stress-inducible chaperones mediating outer mitochondrial membrane TOM70 insertion protective against diet-induced obesity and diabetes rdcu.be/d5ptF

Thanks to FrezzaLab for the great News & Views on our new paper in Nature Cancer! nature.com/articles/s4301…

Great to see this exciting work published showing how tumor mitochondria can be targeted to enhance anti-tumor immunity. Happy to have been able to contribute!

💫NEW by Puigserver Lab & co: the chaperone PPID drives insertion of the #mitochondria import receptor TOM70 into the mitochondrial outer membrane, regulating body temperature, glucose homeostasis and body weight in #obese mice. 👉rdcu.be/d8atv nature.com/articles/s4155…

New preview just published in Molecular Cell! We highlight exciting work by Chen et al. identifying an arginine sensing axis mediated by BAG2 and SAMD4B that promotes survival under arginine deficiency. authors.elsevier.com/c/1lN5t3vVUPVa…