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Combinatorial expression motifs in signaling pathways dlvr.it/T1HwDN

Now online! STING orchestrates the neuronal inflammatory stress response in multiple sclerosis dlvr.it/T8HhbT

The phrase ‘metastasis accounts for 90% of cancer deaths’ is one of the most widely used in cancer research, yet it is overly simplistic & imprecise. Here we dig deeper into the events leading to cancer mortality nature.com/articles/s4156… 1/2

A friend of mine very wisely noted that we have a lot more flexibility to mold this job into what we want than we take advantage of.

REVIEW Nature Immunology Belinda Parker The complexity of immune evasion mechanisms throughout the metastatic cascade nature.com/articles/s4159…

Inspiring… what important questions are we working on 😅 podcasts.apple.com/us/podcast/nig…

How do T cells reach melanoma brain tumors? Using in vivo microscopy, we discovered a new route for T cells to enter the brain via distinct peri-tumoral venous vessels. Our newest paper is now online Immunity. authors.elsevier.com/sd/article/S10… A 🧵👇

Using data from a cohort of 402 #LungAdenocarcinoma patients and from multiple independent cohorts, DNA #Methylation signatures were evaluated to build and validate an accurate model predicting #BrainMetastasis development. Jeffrey Zuccato gelareh-zadeh nature.com/articles/s4159…

Today we report Evo, a generalist foundation model for biology, on the cover of Science Magazine. Trained on billions of DNA nucleotides, Evo was designed to capture two key aspects of biology: the multi-modality of the central dogma and the multi-scale nature of evolution.

7/Epigenetic states define disseminated tumor cell (DTC) fate. In this study, the authors find that hypomethylated DTCs respond to WNT ligands, extravasate and undergo dormancy, while methylated DTCs proliferate intravascularly. Moritz Jakab Hellmut Augustin nature.com/articles/s4301…

Congratulations to Rumya Mirco J. Friedrich Daniel Strebinger Blake Lash Cyrus Biotechnology and colleagues on an exciting study combining AI and protein engineering to minimize the immunogenicity of Cas9 and Cas12a nucleases. These approaches have the potential to improve the safety and

See our recent Nature Biotechnology study SCP-Nano in flow! Mapping LNPs, AAVs, and DNA nanostructures to track targeting & unseen toxicity before clinical trials 🤩. Already >190K access, the most in recent years! 👇🏼 nature.com/articles/s4158…

nature.com/articles/s4159…

Temporal dynamics of immune cell transcriptomics in brain metastasis progression influenced by gut microbiome dysbiosis Cell Reports Samantha Golomb cell.com/cell-reports/f…

Worked on this for a long time and happy to publish what is hopefully just the beginning stages of an interesting sub-field of brain metastasis research! Thank you to S.Zhang Lab, co-authors and labmates🤓🍀🤠 Notre Dame Biology UTSWCancerBio tinyurl.com/yh6wb9wt

The Department of Pathology at UT Southwestern (UT Southwestern Medical Center) is looking to recruit exceptional tenure-track/tenured basic science and translational investigators at all career levels! Please spread the word and see link below for more information. jobs.sciencecareers.org/job/670469/ten…

Thank you Elina and Dmitry for highlighting our study and its impact on advancing our knowledge of TAM regulation and myeloid therapeutics. cell.com/cancer-cell/fu…

Why I teach my students about scientific failure | Science | AAAS science.org/content/articl…

Congrats to our recent Pathology UTSW Graduate School of Biomedical Sciences students for receiving their PhDs! 🎓 Dr. Ryan Kowash – Cancer Bio (Mentor: Esra Akbay) Dr. Samantha Golomb – Cancer Bio (Mentor: Siyuan Zhang) Dr. David Sanchez – Genetics, Development & Disease (Mentor: Diego Castrillon)

📢 Introducing Biomni - the first general-purpose biomedical AI agent. Biomni is built on the first unified environment for biomedical agent with 150 tools, 59 databases, and 106 software packages and a generalist agent design with retrieval, planning, and code as action. This