🚨Latest #FreeRead in JICE Comparative Arrhythmia Patterns Among Patients on Tyrosine Kinase Inhibitors Chen Wei, MD MBA Muhammad Fazal Ridhima Kapoor Sanjiv Narayan Paul J Wang, MD Ronald Witteles Alexander Perino Paul Cheng June Rhee & Tina Baykaner 📖rdcu.be/ddElu #EPeeps

Delighted to have contributed to Derek Klarin & Scott Damrauer's GWAS of thoracic aortic aneurysm / dissection in VA Research MVP. Top 5th percentile of TAAD PRS leads to ~2.5-fold risk for TAAD & ~4.2-fold risk for TAAD-associated death. nature.com/articles/s4158… Nature Genetics

In this compendium review, we delve into the significant impact of adverse environmental exposures on early cardiovascular health. Air Pollution, Built Environment, and Early Cardiovascular Disease | Circulation Research ahajournals.org/doi/10.1161/CI…

Great day for ATTR Amyloid patients. (1) Further proof piling on mountain of evidences that tetramer destabilization is a critical step in the pathogenesis. (2) Finally, some eventual price pressure on Tafamidis for those paying thousands a year for a life-saving drug

Increased lysyl-oxidase-mediated cross-linking of collagen fibers improves biomechanical structure and function of the aorta of a mouse model of Marfan syndrome ahajrnls.org/3Ql246p

Very timely and comprehensive single-cell ATAC-seq benchmarking study of 8 different protocols and 47 PBMC datasets including new analysis pipeline, integrated reference, and best practices. ⁦@steinaerts⁩ ⁦Holger Heyn⁩ ⁦Nature Biotechnology⁩ nature.com/articles/s4158…

(1/2) Huge congrats to the AMAZING #SulaimanSomani, StanfordMedRes PGY-3 and future Stanford Internal Medicine Chiefs, on his #ESCCongress presentation validating the “W-S” method for #LVH detection on the ECG. The beauty is in its simplicity — QRS complexes running into one another! 😮😮😮

📢Excited to announce EchoCLIP, or vision-language foundation #AI model for #echofirst interpretation. Using over 1,000,000 cardiac ultrasound videos paired with expert cardiologist interpretations, we enable #echofirst semantic search and zero-shot predictions. EchoCLIP can

Awesome job by the team ⁦Fatima Rodriguez⁩ ⁦Alex Sandhu⁩ Drs. Peng, Maron et al. A great example of how we can use ALREADY existing data to potentially save lives! sciencedirect.com/science/articl…

Association of NOTCH3 with Elastic Fiber Dispersion in the Infrarenal Abdominal Aorta of Cynomolgus Monkeys@alan_daugherty Hong Lu Sohei Ito Naofumi Amioka Hisashi Sawada ahajrnls.org/3tJ9UO9

Excited to report our recent study regarding the prognostic implication of CHIP among MM patients undergoing HCT with Saro Armenian City of Hope, published in JAMA Cardiology. We asked whether CHIP detected at the time of HCT is associated with increased risk of CVD among MM patients.

Excited to share our research identifying novel genetic underpinnings and mechanism of coronary calcification with sulfatases. Wonderful collaborative effort across multiple institutions! Paul de Vries Kuldeep Singh ⁦⁦Clint Miller⁩ Pat Peyser nature.com/articles/s4416…

Our study is out nature. We identify non-lipid risk pathways for coronary artery disease using pooled CRISPR-interference for 2,285 genes at GWAS loci. With an amazing team we identified the genetic risk pathways for CAD that act in endothelial cells. nature.com/articles/s4158…

Research| With a genome-wide #CRISPR screen in #iPSC, the authors identify the acetyl-lysine reader BRD4 as a regulator of cardiomyocyte differentiation that they subsequently validate in vivo PennCVI Gladstone Institutes UPenn CDB Penn Epigenetics UCSF Cardiology 👉rdcu.be/dzrQm

We know the importance of subtle gene dosage variation, and yet the main tool of molbio is gene KO/KD. In our new preprint, Júlia Domingo introduced subtle modulations of transcription factor dosage by CRISPRi/a, and quantified responses by scRNA-seq. 1/ biorxiv.org/content/10.110…

What if 1 million scRNA-seq libraries can be prepared within $1k? Here we go 👉 21 million cells from 623 mouse tissues, spanning 5 life stages & 3 genotypes, all in a SINGLE study by ONE remarkable student Zehao Zehao Zhang from our lab Rockefeller University! shorturl.at/epsz7

Cheng lab mini-retreat at Napa Valley prior to attending the fantastic #KSVascular24. So proud of Wenduo Gu and @ William_Jackson for a fantastic pair of talks!

Excited to share our #echofirst foundation model is now published in Nature Medicine! Trained on 1M Cedars-Sinai A4C echo-report pairs, EchoCLIP has strong performance on wide range of cardiac diagnostic benchmarks, including LVEF in Stanford Medicine videos (MAE 7.1%).

Excited to share this manuscript on #atrialfibrillation in #ATTR #amyloidosis.🫀AF is common, is associated with a worse prognosis, but not independently of other risk factors. No impact on #tafamidis effectiveness. JACC Journals Pablo Garcia-Pavia Margot Davis sciencedirect.com/science/articl…

🚨🚨🚨 MAJOR news in the #amyloidosis world this morning with positive topline results of #HELIOS-B. #Vutrisiran met all primary & secondary endpoints. Let's break down what we know... #StanfordAmyloidCenter (1/13)