Online now! PKC downregulation upon rapamycin treatment attenuates mitochondrial disease dlvr.it/Rndqdf

Coping with starvation: Cysteine keeps mTORC1 suppressed to ensure survival dlvr.it/SPzJH4

TOR regulates variability of protein synthesis rates | The EMBO Journal embopress.org/doi/full/10.10…

The micropipette—that ubiquitous tool found in laboratories around the world—was invented by a 32-year-old German postdoc in 1957 after a particularly productive two-day tantrum. That first device, made by Heinrich Schnitger, had “all the essential features of the modern

Escherichia coli bacteria (E. coli) can convert a molecule derived from a waste plastic bottle into paracetamol, a pain medication also known as acetaminophen, according to a paper in Nature Chemistry. go.nature.com/3G8s966

1/🚨 New preprint out!🚨 We uncovered that #PI3K-driven wild-type RAS activation bypasses #KRAS inhibition in pancreatic adenocarcinoma (#PDAC) to drive #resistance. 🔑PI3K isn’t just a downstream RAS effector – it can be an upstream RAS regulator. 📄 biorxiv.org/content/10.110…

First to show taurine's binding dynamic with its transporter. Also report how taurine link to senescence. rdcu.be/euqAQ

Scientists find that a possible cancer drug target is also an essential guardian of the blood-CNS barrier, a new Review explores research deciphering the mystery of a conserved brake on mTORC1, and more in this week’s issue of #ScienceSignaling. scim.ag/4lJ76Gv

1/ 🚨 Our new paper is online in nature ! As its first author, I’m enthusiastic to finally share it with you all!🎉 🧠 We discovered a mechanistic link between cellular energy metabolism and the control of the need to sleep 💤 👉 nature.com/articles/s4158… Department of Physiology Anatomy & Genetics (DPAG) 🧵👇

The source of dietary fat influences anti-tumour immunity in obese mice go.nature.com/4o2w4CJ

Potato evolved from tomato 9 million years ago. cell.com/cell/fulltext/… Natural History Museum Sandra Knapp University of British Columbia Loren H. Rieseberg Sichuan University Jianquan Liu #CAAS Sanwen Huang @cellcellpress

Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxide go.nature.com/45khspF

Lactate signalling leads to aggregation of immune-inflammatory hotspots and SLC5A12 blockade promotes their resolution go.nature.com/4miXXoV

New! Online now: Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control dlvr.it/TMK2zc

This newly published report by Iain Campbell, Ph.D. is worth reading (nature.com/articles/s4138…). I appreciate their rigorous approach to revealing the metabolic foundation of bipolar disorder, including not only the seasonality of the disorder, but also some traditional and effective

d-cysteine impairs tumour growth by inhibiting cysteine desulfurase NFS1 go.nature.com/45eETlB

Interesting-Targeting the MYC oncogene with a selective bi-steric mTORC1 inhibitor elicits tumor regression in MYC-driven cancers: cell.com/cell-chemical-…

Species-specific serine metabolism differentially controls natural killer cell functions go.nature.com/46TOvDv

We noticed that Complex II assembly factor SDHAF2 accumulates in some OXPHOS deficient cell lines but not others (1/2) science.org/doi/10.1126/sc…

Very interesting to know, if you block conventional CyclinB-CDK1 interaction, CDK2 can form a complex with Cycling B, which in turn activates spindle assembly checkpoint to induce apoptosis. nature.com/articles/s4158…