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New Paper Alert 🥳Our work showing that histone modifications are critical for regulating the specification of epiblast and primitive endoderm lineages in rabbit blastocysts has just been published ! rdcu.be/d52Qv

Efficient installation of heterozygous mutations in human pluripotent stem cells using prime editing biorxiv.org/content/10.110…

📣 #ISSCR launches international consortium to enable the widespread, responsible adoption of human stem cell-derived disease models for drug discovery. #stemcells #diseasemodeling #drugdiscovery isscr.org/isscr-news/iss…

How neural stem cell therapy promotes brain repair after stroke: Stem Cell Reports cell.com/stem-cell-repo…

Cell-context response to germ layer differentiation signals is predetermined by the epigenome in regionalized epibl… pubmed.ncbi.nlm.nih.gov/40442089/

Non-canonical enhancers control gene expression and cell fate in human pluripotent stem cells biorxiv.org/content/10.110…

An atlas of TF driven gene programs across human cells biorxiv.org/content/10.110…

New research from UCSF School of Medicine & Yale School of Medicine characterizes mouse beige #adipose depot showing conserved features with human supraclavicular brown adipose tissue, providing a preclinical model of human beige adipose tissue development and maintenance ow.ly/ilBo50W19rm ISSCR

Curated to complement the ISSCR Annual Meeting in Hong Kong #ISSCR2025 next week, our 'Focus on stem cells' subject collection highlights recent research & review-type articles discussing the wide range of studies using stem cells. journals.biologists.com/dev/collection…

Using #neuroectoderm #organoids derived from mouse embryonic #stem cells, this study shows a zinc finger-dependent role for #PRDM13 in regulating retinal progenitor cell fate through #WNT signaling. ow.ly/l5EH50W1a1F U-M Kellogg Eye Center University of Michigan ISSCR

New study published in Stem Cell Reports from Memorial Sloan Kettering Cancer Center identifies two enhancers essential for regulating #NANOG expression in human embryonic #stemcells ow.ly/JaI450W1bVa ISSCR Cell Press Gairdner Foundation The Hospital for Sick Children (SickKids)

A new resource of clonal pluripotent human stem cell lines exhibiting inter- and intra-embryo consistency and variability biorxiv.org/content/10.110…

the-scientist.com/from-the-front…

New study finds that inhibition of GSK3α increases GSK3β protein levels and enzymatic activity in mESCs via its glycine-rich region at the N terminus of GSK3α. bit.ly/43QBzLp ISSCR Cell Press Gairdner Foundation The Hospital for Sick Children (SickKids)

Review of preclinical & clinical milestones of allogeneic off-the-shelf CAR-engineered cell therapies, outlining genetic designs, scalable workflows, early-phase trial outcomes, challenges, & more! bit.ly/3SEKmLm ISSCR Cell Press Gairdner Foundation The Hospital for Sick Children (SickKids)

Excited to share our new study in Cell—congrats to Daniel, co-authors, and our collaborators in the Peter Ly What began as pure curiosity led to a tool for modulating mitochondrial abundance in vitro and in vivo. A new direction for the Wu lab begins! cell.com/cell/fulltext/…

In the June issue of Stem Cell Reports, Mason, Nie, Coca, and Andrews review evidence that human pluripotent stem cells occupy transient, metastable substates that influence their differentiation outcomes. Read more: cell.com/stem-cell-repo…

Stem cell-based embryo models: The 2021 ISSCR stem cell guidelines revisited pubmed.ncbi.nlm.nih.gov/40499509/

A novel self-organizing embryonic stem cell system reveals the role of WNT signaling parameters in anterior-posteri… pubmed.ncbi.nlm.nih.gov/40502199/

Explore the Stem Cell Reports Best Of 2024-2025 issue to read the most notable papers published over the last year. ow.ly/29Y950VWsC7 ISSCR