🎉New paper🎉Have you ever tried to capture both daughter cells after a burst of mutagenesis? Paul did, and found mirror-image mutation phasing of #LesionSegregation

Single-mitosis dissection of acute and chronic DNA mutagenesis & repair Nature Genetics

Happy to have contributed!

Robertsonian #chromosomes result from the fusion of two acrocentric or telocentric chromosomes. Jennifer Gerton suggests fusion events are driven by sequence homology (e.g., repetitive #DNA ); recombination initiation during #meiosis ; and physical proximity of fused sequences

Our new paper is out Genome Biology . A close collaboration w/ Yeger-Lotem Lab in which we explore the genomic features that shape aneuploidy patterns in human cancer. Kudos to Juman Jubran & Rachel Slutsky for spearheading this research!

link.springer.com/article/10.118…

Happy to announce that my most recent PhD work from the The Nogales Lab UC Berkeley is out on bioRxiv! We teamed up with Ahmet Yildiz to explore how HURP and Kif18A work together to make sure chromosomes are properly aligned during cell division.🧵⬇️
biorxiv.org/content/10.110…

I don't work on mitosis so often anymore, but catching chromosome condensation like this on a regular old widefield will never ever get old to me

Excited that Brittany “Remission! cont.” Salazar's work on KIF15-dependent spindle assembly is now in press at Mol Biol Cell! In brief, Brittany shows that PRC1 is required for KIF15-dependent spindle assembly and that elevated PRC1 levels promote resistance to Eg5 inhibitors. Link will be posted soon!

Excited to share our latest collaborative work on the 'hierarchical determinants of the oxidation-induced mutational landscape in human cells.' biorxiv.org/content/10.110…
An awesome experience combining powerful cell biology, genomics, and structural biology approaches.

Pleased to share our latest publication in The EMBO Journal on the role of DNAJC9, a J-domain protein in restricting CENP-A mislocalization. NCI Center for Cancer Research
embopress.org/doi/full/10.10…

Happy to share our recent work on transcription-coupled repair of DNA-protein crosslinks. A joy to work with the Twitterless Aleida Acampora and Julian & co Julian Stingele & Lab, among many others across Steve Jackson Lab CRUK Cambridge Institute, Martijn Luijsterburg, Sheera Adar.

nature.com/articles/s4155…

Over the past few years my lab has developed new uses for reversible replication barriers in vitro. Emma Vontalge and Tata Kavlashvili outline our most up to date protocols in Nature Protocols. We hope the community finds this resource useful! 🧬🚦
nature.com/articles/s4159…

#Eclipse2024 in Dallas UT Southwestern Medical Center

Please see our latest findings on how BLM helicase orchestrates the damage response that executes Alternative Lengthening of Telomeres. cell.com/molecular-cell…. Great work from Haoyang Haoyang Jiang and Tianpeng Tianpeng Zhang in collaboration with Hardeep Kaur and Patrick Sung.

Thank you Arun Kumar Ganesan for the kind invitation to share our work UNM Health Sciences!

The Cape Sounio EMBO meeting on 'The DNA Damage Response in cell physiology and diseases' is now open for registration! 👇 Deadline May 17th!
meetings.embo.org/event/24-dna-d…

My lab is hiring postdoctoral researchers. Passionate about scientific discovery? Looking to join a dynamic, diverse and welcoming team? Intrigued by genome function and stability deregulation in cancer? This may be a great opportunity for you. #CancerResearch

Happy to share our findings on the benefits of extra centrosomes acting as cancer barrier by the induction of BCL2 regulated cell death. Med. Uni. Innsbruck CeMM
science.org/doi/10.1126/sc…
Thanks to Vincent and Gerlinde , and Fabian to kick off this project

NIG offers Postdoctoral Fellowship:
bit.ly/49oGIv1
If you are interested in live-cell imaging/analysis to reveal how chromatin behaves in living cells and how its behavior contributes to cellular functions, please DM me!
bit.ly/3m6GG8y
bit.ly/390MHwZ

Updated:
🧬DNA repair/genome stability conference calendar🧬
Now includes 2024/25 meetings.
Please send a reply if you have another meeting to suggest: docs.google.com/spreadsheets/d…

We’re #hiring ! Multiple #postdoc positions will be available in my lab to study DNA damage response signalling from June onwards. Get in touch with your CV if interested. Please RT!