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hot take: AI should learn like the human brain. it sees things (computer vision) it touches things (sensing) it tastes things (electronic tongues) it hears things (audio) it smells things (digital smell) not just through large language models (LLMs).

New online! Redefining cellular reprogramming with advanced genomic technologies bit.ly/3KT3kx7

RESEARCH | JH Li, TE O’Sullivan (UCLA) et al.: The overlapping and divergent metabolic requirements of human and murine NK cells in response to activation, with a focus on serine metabolism nature.com/articles/s4225…

Rethinking relief: Targeting sensory neurons to combat cancer and pain dlvr.it/TNkxSq

Congratulations Matteo Matteo Ligorio & UTSW Surgery UTSW Simmons Cancer Center collaborators for this nature Medicine 📝 describing the end-of-life CTCs & vascular invasion dynamics in cancer patients. Tremendous work to elucidate the cause of cancer-related death .nature.com/articles/s4159…

Epitranscriptomics #PhaseSeparation m6A-modified #EnhancerRNA & YTHDC1-BRD4 assemble transcriptional condensate Methylation-inscribed nascent transcripts/MINT-seq detects >3-fold more m6A peaks than MeRIP-seq Stringtie annotate eRNAs & (promoter upstream antisense) uaRNAs, 24%

cell.com/cell/abstract/…

📢It’s now out in ⁦Nature Genetics⁩! 🎉Congratulations to our amazing team ⁦Yibo⁩ ⁦Michael Green, PhD⁩ and wonderful collaborators ⁦⁦MD Anderson Cancer Center⁩ #SpatialOmics #TME #inflammatory niches 🌟Data & Code are publicly available nature.com/articles/s4158…

Sensitive dissection of a genomic regulatory landscape using bulk and targeted single-cell activation. #GenomicRegulation #Genomics #SingleCell #RNAseq Cell Genomics cell.com/cell-genomics/…

Extrachromosomal DNA–Driven Oncogene Spatial Heterogeneity and Evolution in #Glioblastoma doi.org/10.1158/2159-8… By Imran Noorani, Magnus Haughey, Mischel Lab, Charles Swanton, Benjamin Werner, and colleagues #ecDNA Barts Cancer Institute (Queen Mary) @UCL The Francis Crick Institute Stanford University Cancer Grand Challenges

Online Now: Functional pseudo-synapses: A new nexus in extracranial cancer dlvr.it/TNsk95

The big picture: Tracing the arc of conceptual milestones in life sciences over the past century, centered around major discoveries driven by evolving technologies. We are excited about the progress & the research enabled by tech from Parallel Squared Technology Institute (PTI). youtu.be/SrzoLGBVTsY?si…

nature.com/articles/s4155…

science.org/doi/10.1126/sc…

.Nature Genetics paper by bizarMD Herbert Irving Comprehensive Cancer Center Cellular states associated with metastatic organotropism & survival in patients with #PancreaticCancer “pre-existing cellular states within primary tumors appear to guide organ-specific metastatic relapse” nature.com/articles/s4158…

cell.com/immunity/fullt…

nature.com/articles/s4158…

🆕Review article in press: Intratumoral heterogeneity and immunotherapy resistance: clinical implications. Read it here: annalsofoncology.org/article/S0923-…

Amazing study by Anne and co. demonstrating the role of PU.1 in maintaining the microglia homeostatic state nature.com/articles/s4158…

The role of senescent cells in pre-cancer lesions and how they can be targeted for prevention cell.com/cancer-cell/fu… Cancer Cell