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scienceblog.cincinnatichildrens.org/milk-eliminati… #raredisease

Secreted partnerless Ebi3 may bind to cytokines within the extracellular microenvironment and act as a cytokine sink Vignali Lab J Immunol journals.aai.org/jimmunol/artic…

TLR7 activation by imiquimod in MoDCs triggers mROS production, leading to enhanced IL-12 secretion and subsequent NK cell activation J Immunol journals.aai.org/jimmunol/artic…

Microfluidic-based lymphoid organ-on-chip recapitulates antigen capture/expression, CD4+ T cell/B cell clustering, memory B cell amplification, plasmablast differentiation, and antibody secretion in response to perfused proteins or mRNA vaccines JExpMed rupress.org/jem/article-ab…

The gang is back together in Miami! CordBloodAssociation James Ropa

Complex relationship between whole body metabolism, NK cell homing, NK cell metabolism and anti tumour responses Nice new study from Joseph Sun Lab Fasting reshapes tissue-specific niches to improve NK cell-mediated anti-tumor immunity cell.com/immunity/abstr…

Excited to share our new paper on temporal analysis of vaccine+/- adjuvant hours to 100 days (14 time pts). Vax alone induces new baseline immune state early & persists to 100 days, and that state predicts vax responses in an indep cohort. cell.com/cell-reports/f….

Mechanical force matters in early T cell activation | PNAS pnas.org/doi/10.1073/pn…

Vanishing twin syndrome contributes to a birthweight disparity between infants born to Black and white women in the United States Science Advances science.org/doi/10.1126/sc…

Neuroimmune interactions negatively affect host protection against Gram-negative pneumonia and pneumonic sepsis Science Advances science.org/doi/10.1126/sc…

Spatial and single-cell multi-omics profiling of human thymus delineates distinct intermediate thymocyte states during αβ T development and previously co-localization of CD8αα with memory B cells and monocytes nature.com/articles/s4146…

REVIEW Nature Rev Immunol The renaissance of oral tolerance: merging tradition and new insights nature.com/articles/s4157…

CRISPR deletion of PHD2 & 3 stabilizes HIF-1 signalling, in activated CD8 T cells, boosting effector functions, glycolytic flux, and adoptive antitumor immunity in mice via HIF-1α nature.com/articles/s4146…

Efferocytosis drives a tryptophan metabolism pathway in macrophages to promote tissue resolution Nature Metabolism nature.com/articles/s4225…

Pretrainable geometric graph neural network for antibody affinity maturation nature.com/articles/s4146…

"IgE plasma cells are unique" Jamie Orengo summary of the paper in Science Immunology Regeneron science.org/doi/10.1126/sc…

Human MAIT cells exhibit tissue site–dependent adaptation and functional specialization Science Immunology Johan K. Sandberg Tobias Kammann science.org/doi/10.1126/sc…

Intrinsic and extrinsic signaling within an adult skin niche confers specialized Langerhans cell identity on recruited monocytes Science Immunology Clare Bennett Marta E Polak Anna Appios science.org/doi/10.1126/sc…

Between 800,000 and 900,000 years ago, the population of human ancestors crashed, a 2023 Science study finds. The results suggest there were only ~1280 breeding individuals during the transition between the early and middle Pleistocene. scim.ag/8hk #ScienceMagArchives

Waggoner Lab ncbi.nlm.nih.gov/pmc/articles/P…