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It's really hard for me to state in words how important I think these two sister Perspectives are for the future of bioimage analysis. Kudos to all the authors on their extraordinary efforts. It's been a fun ride handling these papers.

#Cellpose 3! Not all images are perfect. Restore your images with Cellpose3 to get better segmentations, w/ Marius Pachitariu biorxiv.org/content/10.110…

Much improved review on conformational entropy from James Fraser (A$AP J) and me. Despite the entropy loss during folding, proteins retain substantial conformational entropy as they fluctuate between conformations in their native state. chemrxiv.org/engage/chemrxi…

What does it take for an ‘AlphaFold Moment’ in functional protein engineering and design? go.nature.com/4bLthb0

Latest from our conformational ensemble prediction pipeline with modified AlphaFold2: This is NOT a trajectory from MD! It took two hours to predict this conformational ensemble using one GPU. The experimentally-resolved energy barrier for this transition is > 15 kcal/mol

This week, we released a groundbreaking 160 entries from time-resolved #CryoEM capturing G protein activation by a #GPCR. It’s the largest data set from a single publication and describes the order of events driving G protein activation upon GTP binding!

💡 FRETpredict is published 💡 We developed code to enable easy calculation of FRET efficiencies from large conformational ensembles using rotamer libraries for many common linker-dye pairs. 📜 doi.org/10.1038/s42003… 💾 github.com/KULL-Centre/_2… 🖥️ github.com/KULL-Centre/FR…

Protein sequences from certain species (e.g. humans, mice, and E. coli) have systematically higher likelihoods than others! Further, we find that this bias can be detrimental for some protein design applications. 2/

Our (news&) views on new monomeric StayGold variants can be accessed here: rdcu.be/dBbnS I hope you enjoy reading it!

Ending my several year long Twitter (X?) hiatus to celebrate my first-first author paper, out today in Nature Computational Science!

(1/5) Attention, Cellular Imaging Enthusiasts! Thrilled to share that our Analysis "The Multi-modality Cell Segmentation Challenge: Towards Universal Solutions" has been published in Nature Methods (@NatureMethods) 🎉🎉🎉 Cell segmentation is a critical component of

#Cellpose remains the state-of-the-art for cellular segmentation. See our new paper, in response to Ma et al, Nat Methods 2024. Paper: biorxiv.org/content/10.110… Leaderboard results ⬇️⬇️⬇️

Our paper "The landscape of biomedical research" is out in Patterns, a Cell Press journal! Great job by Rita González Márquez @ritagonmar.bsky.social. cell.com/patterns/fullt… Amazing interactive explorer by Ben Schmidt / @[email protected] from Nomic AI: static.nomic.ai/pubmed.html For details see my original Twitter thread: x.com/hippopedoid/st….

Nobel Laureate David Baker on the phone with fellow awardees Demis Hassabis and John Jumper. The trio discussed how their teams have inspired one another and what the future may hold.