Twitter Beğeni Hilesi

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent immune response against a distant tumor. Y. Erin Chen, MD PhD led the charge w/ help from Djenet Bousbaine, Alessandra Veinbachs, Belkaid Lab. Science Magazine 1/26 science.org/doi/10.1126/sc…

Our liquid biomarker study of the phase 2 INTEGA #AIO trial is now out Journal for ImmunoTherapy of Cancer jitc.bmj.com/content/11/6/e…. Efficacy of chemo-free regimen (Ipi+Nivo) not compromised in EGA patients with high T cell repertoire, no CTCs or HER2- CTCs. Thanks to everyone involved! Joseph Tintelnot, MD

Macrophages mess with ❤️ rhythm ⚡️ transcriptomics and protein data describe 3-fold expansion of these leukocytes in patients with atrial fibrillation. Among the top expressed genes: osteopontin (SPP1), catalyzing atrial fibrosis and inflammation ❤️‍🔥 science.org/doi/10.1126/sc…

#ScienceSaturday CD8+ T cells classically kill tumor cells by recognition of peptide antigens in the context of class I MHC molecules, and downregulation or loss of class I expression can lead to tumor escape. Emily Lerner et al have now shown that CD8+ T cells can kill class I

I think we need to talk about how devastating this cancer microbiome refutation paper from Steven Salzberg 💙💛 and colleagues is. It really speaks to how devoid of critical thinking and intellectual depth our glam publishing ecosystem has become. 1/n biorxiv.org/content/10.110…

Thrilled to see our #microbiome #immunology paper is out in nature! We mapped T cell receptor specificity to the gut microbiome at the level of a single TCR versus a single strain. nature.com/articles/s4158… Here are highlights of our findings.

#ScienceSaturday While many of you have heard of the microbiome which describes the bacteria in our body, have you heard of the #mycobiome? This refers to the fungi that can be found in our gut as well as in tumors. In a recent report in Cancer Cell, investigators found that

💥BIG PAPER ALERT💥 So excited to share our latest, out now nature! Here, we uncover a spatially confined interplay between subsets of IL-1b+ macrophages and tumor cells that fuels pathogenic inflammation in pancreatic cancer (1/n) nature.com/articles/s4158…

We made a short video to explain the findings of these papers to a lay audience. This was arguably harder than publishing the actual papers. UCL Cancer Institute UCL Faculty of Medical Sciences CRUK RadNet City of London

Together with IdoAmitLab we’re very excited to introduce BiCE (Bispecific DC-T Cell Engager)- a new platform to engineer immune cell communication for #cancer #immunotherapy. Led by the amazing Yuval Shapir Itai Oren Barboy, now out Cell: cell.com/fulltext/S0092… (1/11)

In the latest issue! A versatile CRISPR-Cas13d platform for multiplexed transcriptomic regulation and metabolic engineering in primary human T cells dlvr.it/T3YJvS

Very cool - rejuvenation of the immune system! nature.com/articles/s4158…

In the latest issue! Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer dlvr.it/T4rrVY

You are what you eat! Macrophages activate different gene expression (and functional) programs to IL-4 based on the type of apoptotic cell they ingested! Cool stuff by Bosurgi lab Science Magazine science.org/doi/10.1126/sc…

Are you interested in microbiota-immune/immune-tumor interactions in clinically relevant settings? Please consider to apply directly or message me. uke.jobs/index.php?ac=j…