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Did you enjoy @crispr2023 or want to come to the next one! The #crispr conference will be in ⁦ChristchurchNZ⁩ organised by ⁦Peter Fineran⁩, ⁦Dipa Sashital⁩ ⁦Gavin Knott⁩ and ⁦Bridget Watson⁩. Check out the website crispr2025.org

Proud to report our work on Type IV CRISPR CasDinG is out today at Nucleic Acids Research! doi.org/10.1093/nar/gk… Notably, each student author (five) was at one time, or is currently, an undergraduate researcher in my lab. Utah State Science, Nucleic Acids Res

A mind-blowing paper has come out today in nature In 2016, JC Venter Institute scientists trimmed a bacterial genome to its barest minimum required for life to synthesize what they called a "minimal genome" (science.org/doi/10.1126/sc…). Today, a group of scientists from

Could not resist. Making that figure in 2019, I thought the newly uncovered diversity of antiphage systems was already incredible. We now know it was just the tip of the iceberg. I hope our new review will help people dive into this wonderful field. rdcu.be/dg3ql.

I am excited to share my postdoc work in the Aaron Whiteley lab where we found bacterial cGAS-like enzymes that produce 2′,3′-cGAMP to activate an ion channel that restricts bacteriophage replication! See the thread for highlights. biorxiv.org/content/10.110…

Mechanistic insights into Shedu antiphage nucleases! While the immune trigger(s) remain enigmatic, the modular N-terminal domain hints at varied infection sensing strategies. biorxiv.org/content/10.110…

💡New #preprint of the NanoDynamics Lab in collab. with Staals & de Ridder labs Wageningen U&R incl. Carlos de Lannoy, Ben Noordijk: #Nanopores reveal the stoichiometry of single oligo-adenylates produced by type III #CRISPR-Cas. doi.org/10.1101/2023.0… Short 🧵.....:

Now online: Antiviral type III CRISPR signalling via conjugation of ATP and SAM. Fantastic work by Haotian Chi and colleagues. nature.com/articles/s4158…

Hard to believe it's been 2 years since we released PADLOC v1.0.0 😱. To celebrate, here's a new major release – 📦 PADLOC v2.0.0, with lots of new systems! 🔥 (available from GitHub/Conda and the PADLOC web server: padloc.otago.ac.nz) 🧵 1/n

Genome editing has revolutionized the treatment of rare disease. What if we could put any change into RNA safely and reversibly? Today we (+ Omar Abudayyeh ) debut PRECISE, allowing for RNA edits, deletions, and insertions from 1 to >1,000nt biorxiv.org/content/10.110… 🧵 1/x

Now online Nucleic Acids Res, our analysis of Type III CRISPR loci in 1000 complete microbial genomes academic.oup.com/nar/article/do…

Higher-order oligomeric assemblies are common across immune systems in all domains of life... 𝘽𝙪𝙩 𝙬𝙝𝙮!? 🤔 Using recent insights into bacterial immunity, we discuss the possible evolutionary advantages of these fascinating architectures🧬🏛️: rb.gy/cbwxxp 1/5