Thanks Lex Fridman for another super fun & wide-ranging conversation. We talked about the future of video games, the nature of reality, advancing science with AI, the path to AGI… and quite a bit more as usual! Always a blast, already looking forward to next time! 😀

If You Want to Learn, Do.

Culture is one of the most over-used yet under-valued terms in organizations. Done right – becoming a set of actions vs just a slogan that is posted in the breakroom – a strong culture can really separate the great from the good. Here are some thoughts I shared with our team on

Dear entrepreneurs, It is a very good idea to include a live demo in your VC pitches. Love, Brian.

Bytedance just made more money than Meta for the first time in history.

Well said

“Money is essentially an information system for labor allocation, so it has no power in & of itself. it's like a database for guiding people as to what they should do.” — Elon Musk

This should be a poster in every classroom.

It costs $0.00 to be an optimist. It costs $0.00 to be kind. It costs $0.00 to think long-term.

Preparando la visita a Almaraz mañana.

I stole this idea and now use it with every single employee. It’s the best illustration I’ve seen of teaching someone to be high agency. It says there are 5 levels of work: Level 1: “There is a problem.” Level 2: “There is a problem, and I’ve found some causes.” Level 3:

You think it's the competition The funding drama Those lost key deals That rough quarter You think those are what wear you down But it's the internal battles that do the real damage

In 1971, money changed from a natural system (gold) to a socialist system (fiat). Crypto is tech to replace socialist money with a free-market system. Market systems are inherently competitive and as tech evolves, new monies will continue to emerge to challenge existing ones.

If I could send my 18 year old self a message, it would have three parts: 1. Prestige is often mistaken. Follow curiosity instead. 2. There's no way to avoid hard work. It's not sufficient, but it is necessary. 3. Don't take your parents for granted.

We don’t need more startup theatre. We need more innovators quietly building and shipping products that feel like magic. Building trust > buzzword filled posts.

Before you sell, Before you quit, Before you step down Remember at best, we have 3 >real< start-ups in us as founders. And often just 1 good one. If you have any traction at all -- maybe find a way to make this one work.

AlphaGenome is our latest & most advanced genomics model published in nature today including making the model & weights available to academic researchers. Can’t wait to see what the research community will do with it. Congrats to the team on our newest front cover! #AI4Science

Sahil Lavingia The best founders I know don't retire — they just upgrade their obsession. The skills that built company #1 become the foundation for company #2, but with better pattern recognition and fewer dumb mistakes. The 'retirement' is just the refractory period between ideas.

If your child becomes a reader, about 80% of the educational job is already done. That's our honest assessment, based on many of us working in education for over three decades. Everything else is secondary. Most parents think science education is important. Yes, it is. But if you