Twitter Beğeni Hilesi

Very nice work! This bias is most noticeable in genes with weak dependency effects where the top correlates are the genes in the same chromosome arm. Very timely, stay tuned for an update on 23Q2 The Cancer Dependency Map Project release where we made a correction that accounts for this effect

The 23Q2 data release is live on depmap.org! We are excited to share new CRISPR and omics data, an update in our CRISPR method, Chronos, a new Target Discovery app and a new cell line page. #DepMapPortal #DepMap #OpenScience #CancerResearch

Use the new TD tool to identify novel genetic targets based on analyses of DepMap CRISPR and RNAi data! Sort or filter genes by pre-computed analysis metrics, including selectivity, predictability and biomarker class, and external annotations for target tractability.

Nature Cancer The following thread is a “tweetorial” on our study Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias nature.com/articles/s4301… rdcu.be/dc490 #mmsm #myeloma #CRISPR Dana-Farber Broad Institute

Nature Cancer Dana-Farber Broad Institute We teamed up with The Cancer Dependency Map Project to systematically characterize the molecular vulnerabilities of MM cells through genome-scale CRISPR gene-editing screens. We also performed further preclinical characterization of key genes selected by these screens (3/n)

New data is live on depmap.org! We are excited to share new CRISPR and omics data, an update in our CRISPR method, Chronos and a new portal interface. #DepMapPortal #DepMap #OpenScience #CancerResearch

Visit us at AACR 2024!🎉 Members from DepMap and PRISM will be at booth 153. Team members will be available to answer your questions about our data, the DepMap portal and provide some tutorials of our portal tools. We look forward to meeting you!

Impressive work using The Cancer Dependency Map Project data to identify DCAF5 as a synthetic lethal target in SMARCB1 mutant cancers. Congrats The Roberts Lab !!!😍

Very excited for #AACR24 in a few days! I'll be discussing some of our recent work in Session AT6 - 'Systematic Functional Approaches for Understanding and Targeting Cancer' (Monday 8th April, Ballroom 6 CF) abstractsonline.com/pp8/#!/20272/s…

Excited to chair a session at #AACR24 on "Systematic Functional Approaches to Understanding and Targeting Cancer" We've got an amazing lineup of speakers ready to share their insights! Alison M. Taylor Chris Tape Alice Berger abstractsonline.com/pp8/#!/20272/s…

Amazing collaboration partners, meet the PRISM team right at their booth. PRISM rapidly screens a wide range of drugs across more than 900 human cancer cell line models using a high-throughput, multiplexed approach. #AACR24 theprismlab.org Francisca Vazquez and Jennifer

Synthetic Lethality at Scale: Francisca Vazquez, Ron Firestein, and Aniruddha Deshpande will address this topic in a plenary session at the AACR Conference on Cancer Synthetic Vulnerabilities (June 10-13, Montreal). Learn more: bit.ly/3WuPLb5 #AACRsynth24 Francisca Vazquez

Genetic dependencies associated with transcription factor activities in human cancer cell lines: Cell Reports cell.com/cell-reports/f…

Great use of The Cancer Dependency Map Project data Congratulations to all involved

🎉New DepMap data and tools available on the portal! We’re excited to release new Omics and CRISPR data to the DepMap portal, as well as a new portal tool, Data Explorer 2.0, and a new DataHub where you can learn more about DepMap’s data structure and how to map data files.

Junior group leader positions at CNIO Stop Cancer: Big Data, AI, Computational Biology, etc... Please help us spread the word. cnio.es/en/empleo/juni…

Impressive resource & dataset for those researching #Cholangiocarcinoma & other #BileDuct cancers. Preprint from Francisca Vazquez Gaddy Getz & Nabeel Bardeesy Mass General Cancer Center Broad Institute. Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and

New iorio Lab Human Technopole Genome Biology paper in collaboration with Broad Institute The Cancer Dependency Map Project shedding further light on structural features causing biases in CRISPR-Cas9 screening data and methods to correct them. More on the thread below 👇 genomebiology.biomedcentral.com/articles/10.11…

Happy to share our lab’s latest work led by Hannah Weinstein and Kevin Hu about the endlessly interesting ribosomal protein RPL22 and its role in splicing and cancer. Thanks to all of our collaborators incl Hani Goodarzi Francisca Vazquez Mahmoud Ghandi cell.com/cell-reports/f…