Tom Powles (@tompowles1) 's Twitter Profile
Tom Powles

@tompowles1

Interested in Urology Cancers, biomarkers and drug development.

ID: 1206580727296544769

calendar_today16-12-2019 14:24:22

1,1K Tweet

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Tom Powles (@tompowles1) 's Twitter Profile Photo
Tom Powles
@tompowles1

7 months ago

TROPICS4 sacituzimab govitecan vs chemo in pretreated UC Annals of Oncology OS & PFS HRs=0.86. RR 23 vs 14, but G3+ TRAE 67 vs 35% with ⬆️ G5 TRD. While there is activity the ⬆️ tox & lower RR compared to EV/erda was problematic. Phase 2 Data on 2 other TROP2/TOPO1 ADCs #ASCOGU25

TROPICS4 sacituzimab govitecan vs chemo in pretreated UC <a href="/Annals_Oncology/">Annals of Oncology</a> OS &amp; PFS HRs=0.86. RR 23 vs 14, but G3+ TRAE 67 vs 35% with ⬆️ G5 TRD. While there is activity the ⬆️ tox &amp; lower RR compared to EV/erda was problematic. Phase 2 Data on 2 other TROP2/TOPO1 ADCs #ASCOGU25