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Our paper with the Boris Lenhard group, showing distinct transcription initiation regulation associated with cell cycle dynamics during zebrafish embryo development, is out in Nucleic Acids Research. tinyurl.com/WraggetalNAR. By Joseph Wragg & L Roos, with Nevena Cvetesic

My street is drenched in darkness. All the windows are blown out and all people inside seem to have left. But one neighbor left a candle in his empty living room and I cannot explain how much calm its small light keeps lending me.

I don't think people are marveling enough that we're about to introduce mRNA into billions of people so that their own cells can translate that mRNA into a SARS-CoV-2 protein, which then triggers an immune response that can recognize the real SARS-CoV-2 virus. How cool is that!

Really excited to share my first PhD work with jesse veenvliet @jesseveenvliet.bsky.social out today in Science Magazine, where we induced trunk-like-structures (TLS) with embryo-like morphogenesis in gastruloids! #MeissnerLab #HerrmannLab MPI for Molecular Genetics science.sciencemag.org/content/370/65…

First Thing xkcd.com/2404/ m.xkcd.com/2404/

Introducing IN SITU GENOME SEQUENCING, a new technology to resolve DNA sequence🧬 and structure🔬 A team effort with Andrew Payne, Paul Reginato, Ed Boyden, Jason Buenrostro, and Fei Chen science.sciencemag.org/content/early/… This is how it works: (1/8)

I am delighted to share with you our work from the MundlosLab at MPI for Molecular Genetics that just came out in nature.

mRNA Vaccine xkcd.com/2425/ m.xkcd.com/2425/

Studying cis-regulatory differences using human-chimpanzee tetraploid hybrid cells - we clearly live in the future.

Types of Scientific Paper xkcd.com/2456/ m.xkcd.com/2456/

You only know what your measurements say about your system to the extent that understand the noise in your measurements. This applies especially to scRNA-seq data, which is subject to severe sampling noise. See here our attempt at solving this problem: zpr.io/RAcSp 1/n

Beautiful mother bat, flying with her baby. 📷@ 360pixual

The functional annotation analysis was performed by Abdul Kadir Mukarram, Piotr Balwierz, Chirag Nepal and Damir Baranašić. The conservation analysis and the development of the comparative epigenomics method was conducted by Tobias Zehnder. (15/n)

Happy to see this huge effort put together and out as a preprint. Congrats to everybody involved and special thanks to Damir Baranašić, Boris Lenhard and ferencmueller for a very fruitful collaboration.

heads up science twitter 📣 the Kraushar Lab has officially started MPI for Molecular Genetics in Berlin! let's tackle the molecular program that builds the brain at high resolution. we 👏 are 👏 hiring – give me a shout! grateful for RTs! molgen.mpg.de/kraushar-lab

Check this cool story about how evolution managed to incorporate a novel gene into an ancient TAD and simultaneously escape co-regulation. Good job Alessa Ringel @mrmikerobson1!

Introducing Mosaic research – a groundbreaking $50 million research initiative in partnership with @nanostringtech, University of Pittsburgh, Gustave Roussy CHUV / Centre hospitalier universitaire vaudois, Charité - Universitätsmedizin Berlin, Uniklinikum Erlangen, aiming to create the largest #spatial atlas of cancer cells. Featured by Financial Times, this

2 months ago I wrote this thread on single cell GPT: "Just as text is made of words, cells are characterized by genes" scGPT sparked fascinating discussions about deep learning & mechanism in biology: where we stand & what lies ahead. Now an improved version of this deep

WARNING Sequence alignment based methods miss most evolutionary conserved enhancers! A fantastic effort led by @mphan232 describes a new strategy and finds 1000s of #conserved #enhancers in distantly related genomes capitalizing on #IPP by Tobias Zehnder 👇 biorxiv.org/cgi/content/sh…