🚨 New publication alert! 🚨 Our latest update on the Chemical Probes Portal is live! 🎉 📜 Read the paper: doi.org/10.1093/nar/gk… 🔍 Learn about our expanded content + improved functionality in the 2024 Nucleic Acids Research Database Issue. #ChemicalProbes #BiomedicalResearch

A well anticipated overview highlighting the first CACHE challenge, which brought together 23 research teams from 10 countries to collectively predict 1,955 compounds targeting LRRK2-a protein linked to #ParkinsonsDisease. pubs.acs.org/doi/10.1021/ac…

A fully open framework for DEL-ML hit discovery. We replace explicit DEL compound structures with ML-ready chemical fingerprints, enabling the broad scientific community to advance DEL-ML models and refine discovery methods. All data available on AIRCHECK. chemrxiv.org/engage/chemrxi…

A 2024 update on Chemical Probes Portal highlights a significant expansion in the number of chemical probes and human protein targets, along with major improvements in expert review processes and user engagement. academic.oup.com/nar/advance-ar…

A comprehensive study that offers validated ligands for future autophagosome tethering compound (ATTEC) development and advances targeted protein degradation strategies. nature.com/articles/s4146…

We report four DCAF1-based PROTACs with endogenous and exogenous WDR5 degradation effects and high-resolution crystal structures of the ternary complexes of DCAF1-PROTAC-WDR5. nature.com/articles/s4146… #PROTACs #DCAF1 #WDR #DrugDiscovery #OpenScience

How does EZH2 inhibition make atypical teratoid rhabdoid tumor cells vulnerable to therapy? A collaborative study using UNC1999, a high-quality chemical probe developed through a collaboration between the SGC UNC Pharmacy. nature.com/articles/s4146…

We have joined the Bluesky community! Follow us to stay updated on our latest research, collaborations, and efforts to shape the future of drug discovery. bsky.app/profile/thesgc…

A summary of the efforts of EUbOPEN, a public-private partnership dedicated to create, distribute and annotate the largest openly available set of high-quality chemical modulators for human proteins. pubs.rsc.org/en/content/art…

New episode for our Target 2035 Podcast Series 🎧 Milka Kostić, PhD talks with aled edwards to unpack his journey from a traditional research scientist to a passionate open science advocate. Listen here: bit.ly/3AZQkBm

Supported by U of T Data Sciences Institute (DSI), a program led by Matthieu Schapira will provide trainees with the skills necessary to interpret complex experimental data and drive breakthroughs in drug discovery. Registration for the first 9-week bootcamp is now open. thesgc.org/news/sgc-launc…

CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson’s Disease Associated Protein pubs.acs.org/doi/10.1021/ac… Cheryl Arrowsmith Ian Dunn aled edwards Lukas Friedrich Francesco Gentile Olexandr Isayev 🇺🇦🇺🇸 Vojtech Spiwok 🇺🇦 Maria Kurnikova Sumera Perveen, PhD Jan Jensen (janhjensen.bsky.social) Matthieu Schapira #JCIM Vol64 Issue22 #compchem

We just launched #MAINFRAME! This international, #OpenScience Network brings #MachineLearning & #compchem scientists together to create open-source algorithms & benchmarks for tackling real-world challenges in #DrugDiscovery. Join us: aircheck.ai/mainframe

#MAINFRAME is launching! This international, #OpenScience Network brings #MachineLearning & #compchem scientists together to create open-source algorithms & benchmarks for tackling real-world challenges in #DrugDiscovery. Join us: aircheck.ai/mainframe

We co-hosted " Target 2035 – A Public-Private Partnership to Accelerate Hit-Finding" along with UCL and Pfizer Inc.. 50 leaders from the pharmaceutical industry, academia, and funding organizations discussed how AI and ML can transform drug discovery. thesgc.org/news/structura…

Researchers at Structural Genomics Consortium (SGC) and The Neuro, along with scientists from 11 major antibody manufacturers, have developed and standardized an #OpenScience platform to characterize research antibodies. YCharOS aims to tackle a critical challenge in biomedical research

A rigorous study of UPS tool compounds for #degrader evaluation is published by Stefan Knapp Structural Genomics Consortium (SGC) in ACS Chemical Biology! They determine the appropriate doses of UPS pathway inhibitors that robustly rescue degradation without displaying off-target activity and toxicity.

We are uniting experts in ML, computational chemistry, and drug discovery to get hands-on experience with AIRCHECK. Co-developed by SGC and University Health Network, AIRCHECK is an open data platform designed to enhance predictive models in drug discovery. Register here: event.fourwaves.com/aircheckworksh…

The AIRCHECK Workshop isn't just another conference! It is an exclusive opportunity to learn, experiment, and get ahead of the curve in ML/AI-driven hit discovery. Register now: event.fourwaves.com/aircheckworksh…

Also in this month's issue is an update on Target 2035 from Cheryl Arrowsmith, Stefan Knapp and colleagues covering the efforts of the EUbOPEN project which is contributing to the goals of #Target2035💡 Read the #OpenAccess article here⬇ pubs.rsc.org/en/content/art…