Peter Choi
@thechoilab
Assistant Professor @PennMedicine and @ChildrensPhila | Interested in cancer genetics and RNA biology
ID: 917507691945299970
http://thechoilab.org 09-10-2017 21:50:55
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Kevin Yang of the Barash (Yoseph Barash) and Choi (Peter Choi) Labs defends his thesis tomorrow! #AlmostPhDone
Very excited to share our paper out today in Nature Methods, introducing TREX (Targeted RNase H-mediated Extraction of X-linked RBPs), a novel approach to reveal proteins that bind to any region of any RNA molecule of interest in living cells🧪: rdcu.be/dyZ2c (1/10)
SpRYgests now enabled via purified SpRY protein through New England Biolabs, available here: neb.com/en-us/products… Super cool to have this option 'live' now - congrats to Russell Walton Kathleen Christie Roman Doll & many others who contributed. Happy SpRYgesting 😃
Our 2nd preprint on thermal control of cells🔥: Below: dynamic thermal induction of stress granules, enabled by new hardware from Will Benman. Why don’t SGs form during every heat pulse?👇 biorxiv.org/content/10.110…
If you’re interested in what the last few years have taught us about the process of splicing, check out our latest review!Congratulations to my co-authors Hope Eliana Merens @karine_choquet Autum Baxter
Why do some patients benefit less than others from precision cancer medicine? We are excited to share our paper "Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling” out in Nature Communications. nature.com/articles/s4146… 🧵
Dysfunction of protein-RNA interactions is linked to human diseases. Pleased to share our review on "Decoding protein-RNA interactions" with discussions on therapeutic applications from knowledge of protein-RNA interactions Nature Reviews Genetics rdcu.be/dNdwp
If you want cutting edge #RNA #Therapeutics leading academia/industry (Adrian Krainer, iMM, ROTEM KARNI, Envisagenics, Remix Therapeutics, Manuel Irimia, Levanon Lab, etc.) this is great location (Porto Portugal) & perfect time (Sep 25-27) - see 👇😀 rnahorizons.com/program/
Our latest work is now published in Molecular Cell! We discovered new RNA-binding zinc finger proteins and demonstrated their functions in RNA splicing, stability, and polyadenylation. Congrats to 1st author @MayaGosztyla and our fantastic collaborators. cell.com/molecular-cell…
Beyond thrilled to present our O-MAP—now *published* Nature Methods (!!!) O-MAP is a powerful new method for biochemically "dissecting" the subcellular microenvironment around an RNA of interest, using off-the-shelf parts and standard manipulations. 🧵 nature.com/articles/s4159…