Trump's economy is being held up by a massive AI bubble. A recent study found that of 300 companies that owned generative AI tools, 95% reported zero return on their investments. We will not entertain a bailout of these companies should this bubble pop.

Today in nature we report a new prime editing strategy that can rescue a common cause of many genetic diseases in a disease-agnostic manner. This approach converts a redundant endogenous tRNA into an optimized suppressor tRNA, enabling a single prime edit to rescue premature

Not sooooo bad: prompt draw a diagram of how 5-HT2A receptor activation induces dendritic spine formation.....I agree with much of this, surprisingly

Liu & colleagues found that #CCL21 enhances #platelet activation & #atherothrombosis via #CCR7 activation. Learn more about a promising treatment for #CAD patients to prevent #thrombosis at ahajrnls.org/4pxSETH

For successful immunotherapy to kill cancer cells, CD8+ T cells (in blue) get into pockets (antigen rich) on the surface of the tumor (here melanoma, in brown) cell.com/cell/fulltext/…

A 2023 Review in Science Translational Medicine looks at the complex connections between astrocytes and other types of cells in the nervous system, including neurons, oligodendrocytes, and microglia. Learn more: scim.ag/3LQSEiZ #ScienceMagArchives

All you need to know about DNA-based recording and how molecular recording can transform the way we study developmental and disease processes The lives of cells, recorded go.nature.com/48kLqeO Free to read here: rdcu.be/d1s8d

How does stress trigger hair loss? Acute stress causes immediate hair follicle necrosis and hair loss via sympathetic nerves, which in turn activates and expands autoreactive CD8+ T cells targeting hair follicles. cell.com/cell/fulltext/…

New Online! Challenges and potential applications of AI in systems biology bit.ly/4p2NAGO

One of the most-viewed PNAS articles in the last week is “The potential existential threat of large language models to online survey research.” Explore the article here: ow.ly/qYLW50XzuBl For more trending articles, visit ow.ly/maUK50XzuBg.

Cell type inference in cell-free nucleic acid liquid biopsy - sevahn vorperian Genentech go.nature.com/4paJOLH

Concerns about genAI related to medical education ebm.bmj.com/content/30/6/4…

An integrated platform for high-throughput phenospace learning of 3D multilineage organoid systems Ryo Okuda et al. doi.org/10.1101/2025.1…

For readers interested in drug repurposing, this article overviews computational approaches to drug repurposing and evaluates available in silico resources rdcu.be/eSY57 nature.com/articles/s4157…

Huge implications for #GPCR-based drug and sensor design Differential Effects of Sodium on Agonist-Induced Conformational Transitions and Signaling at μ and κ Opioid Receptors | pubs.acs.org/doi/full/10.10…

Nature research paper: Architecture of the neutrophil compartment go.nature.com/3MAW8X4

The harmful and biased medical advice from social medial influencers, highlighting lack of expertise, and financial conflicts. Many specific examples and recommendations provided The BMJ bmj.com/content/391/bm…

A statistical framework quantifies single-cell batch variation and recovers meaningful biological signals go.nature.com/4hZnzW5 rdcu.be/eRy6o

Targeted protein degradation is a therapeutic strategy that entails hijacking a cell’s natural pathways for marking proteins for elimination. In a new #ScienceReview, researchers look at recent advances that expand the range or targets, drug modalities, and control mechanisms,

And interesting piece... foreignaffairs.com/united-states/…