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its out its out its out!!! ☺️ my first co-first, out on biorxiv. we determined the structure of connexin32 GJCs and HCs as well as inestigated the N terminus role in HC gating. 🧫🦠 Thanks to all people who worked on this project! Chao Qi Dina Schuster Anand Picotti Lab

Mitochondria have converted codons for amino acids into signals that terminate protein synthesis. Ribosome profiling and cryo-EM uncover a unique conformation between an extension in mtRF1 and the codon, mRNA and rRNA that enables this feat. science.org/doi/full/10.11…

How to stop in a noncanonical way: The Ban Lab (ETH Zurich ), with the Aleksandra Filipovska & Gatfield lab, uncovered the unusual molecular mechanism by which mtRF1 recognizes noncanonical #stop codons in human #mitochondria to terminate #translation! bit.ly/3p49y26 #ribosome

Mitochondria have their own genetic code, breaking the standard rules of protein translation. Combining ribosome profiling and cryo-EM reveals how an unusual release factor protein can replace a tRNA to subvert the standard genetic code. Science Magazine science.org/doi/10.1126/sc…

Wonderful collaboration with Aleksandra Filipovska reveals secrets of non-canonical translation termination in mitochondria. Structural insights and ribosome profiling explain how mtRF1 recognizes noncanonical stop codons in human mitochondria. Science Magazine science.org/doi/10.1126/sc…

Dropping the anchor, how to TRAP a ribosome at the ER membrane! Check out our new study describing a structure of TRAP complex interacting with the ribosome and Sec translocon published today in NatureStructMolBiol nature.com/articles/s4159…

Our story on how TRAP-Sec translocon interactions with the ribosome facilitate membrane protein biogenesis at the ER membrane is now out NatureStructMolBiol. Awesome work by Mateusz Jaskolowski and Martin! The Ban Lab Deuerling Lab D-BIOL @ ETH Zurich UVA School of Medicine Universität Konstanz NCCR RNA & Disease

Translating ribosomes on the ER membrane: the molecular basis of hormone biogenesis and the role of the TRAP complex Kudos to Mateusz Jaskolowski, Ahmad Jomaa, Martin Gamerdinger and everyone else involved from The Ban Lab & Deuerling Lab. More at NatureStructMolBiol! nature.com/articles/s4159…

The power of interdisciplinary research is also reflected in numbers. Exciting ERC synergy grant kick-off meeting combines expertise in biochemistry, structural biology and single molecule biophysics Bukau Lab, Sander Tans and The Ban Lab. A wonderful day of science in Zurich

🇮🇹 #Giro YESSSSSSSS PRIMOZ! STAGE WIN + MAGLIA ROSA!!!! 😍

Another big discovery for NAC role, this time, in mediating nascent proteins processing Deuerling Lab & The Ban Lab. Very happy that I was able to contribute to this wonderful story. Big congrats to Martin, Min and everyone involved!

Dynamic action of MetAP on the translating ribosome - new paper out in Science Magazine from our beautiful collaboration with Deuerling Lab! D-BIOL @ ETH Zurich NCCR RNA & Disease @SNF_ch science.org/doi/10.1126/sc…

Love that guy 💪🏼🏐 bravo Odbojkarska zveza Slovenije 🇸🇮

What do you think is the most underrated city in Europe? I’ll start:

A freeway in Slovenia yesterday. Tadej Pogačar #Giro

I'm excited to share our latest review on mistranslation of the genetic code. I had a great time working with all the authors. A special shout-out to the talented Dominik B. Schuntermann, whose creativity and determination were instrumental. jbc.org/article/S0021-…

Tadej Pogačar is World Champion 🤩🌈 Attacking with 100km to go, the Slovenian completes the triple crown of the Giro, Tour de France and Worlds in one season 👏 #Zurich2024

🤟🤟 Tadej Pogačar 🤟🤟 Men Elite UCI World Champion 🌈 #Zurich2024

Slovenia yesterday became the first nation in the history of cycling to win the Giro d’Italia, Tour de France, Vuelta a España and the World Championships in the same season. WHAT A MOMENT 🇸🇮

100k Dereck Lively II