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I’m really excited to share our new pre-print “Genome-wide Characterization of Diverse Bacteriophages Enabled by RNA-Binding CRISPRi”, with co-first author Muntathar Al-Shimary @doudna_lab and the newly-minted Brady Cress lab! biorxiv.org/content/10.110… 🧵🧵 1/

🔬Our preprint is out! "Genomic plasticity is a blueprint of diversity in Salmonella lineages". 🧬👩‍🔬 Thrilled to contribute to advancing our understanding of Salmonella pathogenesis. A huge thanks to my supervisors, Franklin Nobrega #Research #Salmonella 🌐 biorxiv.org/content/10.110…

Just shared at Keystone Symposia a new @ArcInstitute discovery of the bridge RNA recombinase mechanism: a new class of natural RNA-guided systems that retains the key property of programmability from RNAi and CRISPR while enabling large-scale genome design beyond RNA and DNA cuts

🚨📄PREPRINT ALERT! "New antiviral defences are genetically embedded within prokaryotic immune systems" ⚔️🦠 #phage biorxiv.org/content/10.110…

Excited to see our story on defence system synergy now out in Cell Host & Microbe! 👇 sciencedirect.com/science/articl…

Clinical strains of Pseudomonas aeruginosa have accumulated phage defense systems in their genome matching their broad resistance to diverse phage families. Great work by Rita, Daan and Jelger. Ana Rita Costa, Daan F van den Berg science.org/doi/10.1126/sc…

New preprint! Ben Adler and I @doudna_lab, in collaboration with Emily Armbruster and @JoePogliano, unveil a mechanism for Hachiman immunity. The punchline - Hachiman is a genome integrity sensor. College of Chemistry @igisci HHMI biorxiv.org/content/10.110… 🧵 1/14

Excited to see our work published in nature. Grateful to all the authors for their hard work, the reviewers for their insightful comments, friends for their help along the way.

Exciting times! I will be giving a talk in session 3 about KlebPhaCol make sure to tune in to learn more 👀

Excited to share some recent PhD work together with ruweyda sayid and Anne van den Hurk, a review on Phage-Plasmids (P-Ps) and current knowledge. Fascinating MGEs that need more exploration! portlandpress.com/essaysbiochem/…

1/8 📣Big update: we are very excited to share that the KlebPhaCol bioRxiv is now out! Big shoutout to all those involved in making this happen🙌 Check it out now 👇🏻 biorxiv.org/content/10.110…

Dive into our lab’s first peer-reviewed publication—co-led with our friends Ben Adler and Muntathar Al-Shimary from the Doudna lab! If you’ve already read the preprint, don’t miss the new updates: doi.org/10.1038/s41564… Nature Microbiology

In @nature we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR-Cas9 enzymes, offering safer & more genome editing tools. 🧬🖥️ Rachel Silverstein CGM at MGH @MGH_RI MassGeneral News Harvard Medical School nature.com/articles/s4158…

Excited to share my PhD work… and more CRISPR-Cas9 PAM variants than anybody asked for

Excited to see this work published! Grateful to have contributed. Big congrats to Sukrit, Héloïse Carion, and all other authors👏! Shoutout to ONI for their awesome super-resolution microscope, which we used to show RonA localizes to the membrane when triggered by ArdA!👇