Excited to share the first preprint from the Srinivas Viswanathan Peter Choi labs. Via a genome-scale CRISPR screen, we identified protein arginine methyltransferase 1 (PRMT1) as a vulnerability in CRPC likely through its ability to modulate AR signaling biorxiv.org/content/10.110… (1/4)

Excited to share our latest work showing how the KLF5 oncogenic transcription factor acts in the 3D genome of epithelial cancers. This work continues a tradition of @meyersonlab and Mathieu Lupien alumni/friends Swneke Bailey Peter Choi working together. cancerres.aacrjournals.org/content/early/…

Just published #OnlineFirst: Genetic ancestry contributes to somatic mutations in lung cancers from admixed Latin American populations. From Jian Carrot-Zhang Oscar Arrieta Andres F. Cardona @meyersonlab and colleagues: bit.ly/3mC8oVy Learn more: bit.ly/3lFidkt

Excited to share our work on #rarecancer #rmc #sicklecell trait genomics using linked read sequencing. Awesome collaboration with Matthew Meyerson and his graduate student Kar-Tong Tan, Children’s Oncology Group, along w Elizabeth Mullen, Bill Hahn and many more. rdcu.be/coBkO

Incredible study from Taku Kambayashi demonstrating an unexpected role for T cells in the regulation of sebum secretion and whole body metabolism. science.sciencemag.org/content/373/65…

Congrats to #LaskerAward winners Drew Weissman & Katalin Kariko, Penn Medicine mRNA vaccine pioneers! Their revolutionary work not only set the stage for development of the COVID vaccines, but it’s also showing us what the future of medicine may look like. spr.ly/6010J6bfE

Happy to receive the New Innovator Award from NIH Common Fund to explore crosstalk between epigenetics & RNA splicing! #NIHHighRisk We are hiring postdocs so reach out if you're interested! Congrats to all awardees, esp. fellow CHOP/Penn Liling Wan Mustafa [email protected] & KorbLab

Happy to share our work on repeat-calling errors in nanopore sequencing of telomeres with Heng Li and #matthewmeyerson biorxiv.org/content/10.110…

Congratulations, Taku Kambayashi !

Intriguing study by Taku Kambayashi introducing the concept that the mammalian immune system may impact inheritance across multiple generations of offspring.

Congratulations, Charles Zou!

What if small molecules could allow you to alter protein localization at will? What if they could allow you to turn on specific transcription factors? Our new manuscript reveals bifunctional molecules to do just that. 🧵

Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer dlvr.it/T1ktP1

XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells dlvr.it/T1m3YD

The microbiota and T cells non-genetically modulate inherited phenotypes transgenerationally dlvr.it/T54TQX

We thank NCI for supporting our work in 3D cancer genomics! This work was led by our grad student Katie Mortenson, co-supervised by K-T Varley, with close collaborations from Yang Liu, Jay Gertz , and Swneke Bailey.

We worked together with Sadeem Ahmad, Sun Hur, and others to understand how the PACT protein prevents the activation of the double-stranded RNA sensor PKR by endogenous cellular RNAs. nature.com/articles/s4146…

Just in time for #RNA25, the Cottrell Lab has posted our first independent preprint to bioRxiv. This is the first first-author publication from graduate student Addison Young and the first publication for the four undergraduate co-authors. biorxiv.org/content/10.110… 1/2

So honored to receive a BWF CAMS and thankful to all of my mentors and supporters along the way! BWF Announces 2025 Career Awards for Medical Scientists bwfund.org/news/bwf-annou…

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