Dr Naomi Harvey (PhD not MD) #WearAMask Sandy B Nick Wellings Clare Daly I think part of the problem with brain activity in particular is that increasing blood flow to the brain due to demand for brain activity interrupts the glymphatic system in the brain which is likely always in overdrive in pwME

charlos __________________________________________________ If the glymphatic system is compromised it would be. It is is dysfunctional in many with LC + ME but obvs on an individual level we don’t know. But, intracranial hypertension is implicated as part of the pathology in ME with 83% showing signs of it here frontiersin.org/articles/10.33…

Fantastic talk by Edoardo de Natale at the 34th National Conference of the Hellenic Neurological Society on the role of the #glymphatic system in neurodegenerative disorders #Parkinsons #Alzheimers #Neurology #research #neuroimaging Exeter Med School

Michael Alexander Emmi Skytén Dr Naomi Harvey (PhD not MD) #WearAMask GeoCK WesElyMD Thank you.
We do need a paradigm shift in modern medicine.
Role of pathogens
Inflammation
Neuroinflammation
Blood vessels
Microglia
Glymphatic system
Mast cells
Platelets.
That’s just a few.

Fascinating results on activity-flow coupling 🔥🧠
N&V by Anna Devor:
nature.com/articles/s4159…

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I sometimes look at the brain like a big office building, and at night, while all the workers are gone, the cleaning crew (glymphatic system) comes in, cleans carpet, deep cleans bathrooms & kitchens, takes out all the trash, dusts, etc.

My personal hunch is that the reason I need a lot of 'no thoughts only stimming' time is because it helps my glymphatic system catch up with all the extra cleaning it needs to do

Dr. Praveen Tripathi Sleeping for less than required time is actually Linked to Alzheimer's and many other neurodegenerative diseases , when we sleep the glymphatic system in the body gets activated and clears the toxic metabolites and misfolded proteins, Hence sleep is vital :)

Check out our new paper on cross-vendor test-retest validation of DTI-ALPS for glymphatic imaging with #MarkVCID consortium, we also provide auto-processing pipeline aginganddisease.org/EN/10.14336/AD…

Modulating the glymphatic system to treat Parkinson’s disease dlvr.it/SqpHKJ

What causes the incessant thirst symptom in #LongCovid ? I see it listed in many studies, but never an explanation. I'm always thirsty now. I hydrate well all day w electrolytes. When I first wake I feel like the crypt keeper. Not my worst symptom, but unpleasant. Just curious.

Shane Liddelow 🍊 Jenn Orthmann Murphy Chris Bennett what about myelin lipoma/tumors produced after injury impeding the CSF glymphatic flush of sleep, preventing the brain from being cleaned of some waste each night? If stress hormone accumulate, it is ptSD.

I'm honestly thinking the lymphatic/glymphatic system is trying to move stuff out, but not able to pull it successfully from the tissues (endothelial dysfunction?), so it keeps sending the signal for 'more fluids!'

Kind of like the O2 not getting to tissues makes us breathless.

Dr Claire Taylor Mossy dr jack lambert 🕸️Dr.T, PhD I @remissionbiome Dr Naomi Harvey (PhD not MD) #WearAMask Dr. Gustavo Aguirre-Chang I worry that tremors are related to glymphatic drainage issues.

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Wende Gibbs What causes his confusion? Can I ask which of these images shows the glymphatic sleep pathway, if one does? Is there a way to clear that pathway if you absolutely KNEW it was blocked?

We are very excited to share our most recent publication showing that functional hyperemia drives CSF influx and clearance in mice. nature.com/articles/s4159… Stephanie Holstein-Rønsbo Maiken Nedergaard Michael Giannetto drfelix Verena Untiet Lauren Hablitz 1/9

Dr Naomi Harvey (PhD not MD) #WearAMask Sandy B Nick Wellings Clare Daly You don't really want glymphatic fluid and blood in the brain competing too much

The part of the brain that clears out extra waste/gunk/neurotoxic junk

Is called the 'glymphatic system'

And in the past 10 years or so, our understanding of how that system works has completely changed.

Salk Institute Engle Lab HargreavesLab ReubenShawLab Mara Sherman Lab How about myelin tumors preventing waste disposal during glymphatic sleep flush?

Hugo Chrost The so-called 'glymphatic' system?

A myelin edit surgery is needed. The glymphatic path used by CSF to clean the brain (during sleep) must be kept open and free to flow. A myelin tumor after brain injury is a block of hormones flowing toward the urinary tract, and it must be considered an emergency and removed.

But! If your brain is perpetually using a lot of energy (and the study up thread indicates this seems to be a thing for Autistic people)

Then there isn't as much time for your glymphatic system to clean up excess waste

Especially if you also have trouble sleeping

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