Another CCNF paper out that demonstrates that ALS variant in cyclin F impairs sequestosome-1/p62 foci formation and insolubility link.springer.com/article/10.100….
Supported by
MND Research Australia ChungNeuro Lezanne Dr Rachelle Balez👩🏽🔬🧠🔬👩🏽🎨 Blair Genomics and Cell Biology Lab
This paper driven by AN1RA Natalie Farrawell includes some of my PhD work - iPSC-derived motor neuron ubiquitinomics
🧠An ALS CCNF variant disrupts motor neuron ubiquitin homeostasis
🧠The free pool of ubiquitin is critical in ALS progression
academic.oup.com/hmg/article-ab…
Plant pathogens 🦠 acquired diverse #effectors to exploit the host #ubiquitin -proteasome system. They can hijack it for their own advantage, e.g. to degrade immune components or even suppress proteasome function to mess with host cellular pathways #proteostasis (4/5)
Since my PhD i've been working on the manipulation of the proteasome by🦠& finally we had the chance to write an Annual Reviews on 'The Plant Ubiquitin–Proteasome System as a Target for Microbial Manipulation'with Gautier LANGIN Manuel GF #proteostasis 🧵
annualreviews.org/doi/abs/10.114…
#proteostasis Structural basis of ubiquitin-independent PP1 complex disassembly by p97 embopress.org/doi/full/10.15…
We would like to draw your attention to this public lecture tomorrow 6pm by Prof. Ivan Đikić Ivan Đikić (@IBC2_GU,Goethe-Universität). As part of the #PTM lecture series, he will talk about unconventional #ubiquitin code in #infection & #inflammation .
Livestream available Alfried Krupp Wissenschaftskolleg Greifswald!
The #ubiquitin -proteasome system is involved in the degradation of various immune components (NLRs, receptors, hormone regulators etc.) during plant-microbe interactions highlighting its importance to mount plant defense responses #proteostasis #immunity (2/5)
🎉We are thrilled to share our exciting new collaboration with Inada Lab and jingdong cheng on how Otu2 recognizes and deubiquitinates 40S ribosomes after translation. Here is a thread with the most interesting findings:👇 #ribosome #ubiquitin #cryoEM
😍 Excellent insights into pathogen manipulation of plant ubiquitin-proteaosome system by Şuayb Üstün 🌱👨🏻🔬 Gautier LANGIN and Manuel GF. Very timely 🔥🔥🔥
