New In Science #Immunology: Tumor-produced lactate drives dendritic cell dysfunction in #tumor microenvironment, via cholesterol metabolism regulator #SREBP2. Duke University School of Medicine UNC Lineberger scim.ag/6WQ

Blocking tumor-induced activation of #SREBP2 in #DendriticCells promotes anti-tumor activity in a mouse model of melanoma, according to a new study. Duke University School of Medicine UNC Lineberger 📄: scim.ag/6UO

Sterol Regulatory Element-Binding Protein 2 (#SREBP2). The disruption of this mechanism through genetic or pharmacological means disrupts both lipidomic composition and the biophysical homeostasis of the membrane. 28/nn

#Hypoxia activates SREBP2 through Golgi disassembly in bone marrow-derived #monocytes Tsuyoshi Osawa et al show that low oxygen induces activation of #SREBP2 via #Golgi-ER fusion, causing lipid biosynthesis, myeloid cell infiltration, & #tumorigenesis embopress.org/doi/full/10.15…

🌟Editor's Choice 🌟 🧠Knockout of the #Golgi pH regulator (GPHR) in the brain leads to ▪loss of Golgi integrity ▪#neurodegeneration ▪⬇ #SREBP2 transcriptional activity & ▪⬇ #CholesterolBiosynthesis 👉bit.ly/3UhOxuQ #neuroscience

Irisin inhibits PCSK9 expression through activating AMPK-SREBP2 pathway doi.org/10.1016/j.bbrc… #atherosclerosis #Irisin #PCSK9 #AMPK #SREBP2

🧠The #Golgi pH regulator (GPHR) links ↪Golgi integrity ↪#Neurodegeneration ↪#SREBP2-mediated cholesterol biosynthesis 👀Read study: GPHR-mediated acidification of the Golgi lumen is essential for #CholesterolBiosynthesis in the brain ➡bit.ly/3S7KgcR #neuroscience

📢It's tiiiime for.... Recent Publications by #PHRI Researchers! 📖 Read: PHRI.ca/recent-publica… Nature Communications #caffeine #SREBP2 #LDLR #cholesterol JMIR Publications #mhealth #VERDICT study #virtualcare #remotepatientmonitoring #bloodpressure #wearable JASN_News #genetics #KidneyDisease

Wenjing Du and colleagues show that #p53 directly represses SQLE #transcription to restrict #cholesterol biosynthesis, which is critical for inhibiting #tumor growth. #cancermetabolism #SREBP2 ➡️➡️ embopress.org/doi/full/10.15…

#COVID19-activated #SREBP2 disturbs #cholesterol biosynthesis and leads to #cytokinestorm. Sterol regulatory element binding protein-2 (SREBP-2) is activated by cytokines or pathogen, such as virus or bacteria. SREBP-2 can serve as an indicator for severi…lnkd.in/g6D-RUC

Thought-provoking article in ⁦NEJM⁩ by Winther&Lutgens |The Link between Hematopoiesis and Atherosclerosis | ⁦NEJM⁩ | #AIBP2 #SREBP2 #NOTCH | cc: #CHIPsm ⁦David Steensma, MD⁩ ⁦Peggy Goodell⁩ ⁦Koichi Takahashi⁩ ⁦Siddhartha Jaiswal⁩ nejm.org/doi/full/10.10…

An actionable #sterol-regulated feedback loop modulates #statin sensitivity in #prostatecancer sciencedirect.com/science/articl… #HMGCR #tumor #SREBP2 #PCa

#Genistein upregulates LDLR levels via #JNK-mediated activation of SREBP-2 ow.ly/4wtp300oYHk #LDLreceptor #cholesterol #SREBP2

#ASN2015 #kidneywk #srebp2 pourrait être lien entre statines et psck9