'Explanation Proposed for Long-COVID Symptoms in the CNS'

''The reason why some patients develop neuroPASC is unknown, but I think the evidence has pointed to a role for the immune system rather than the virus itself,' Dr. Spatola said'

medscape.com/viewarticle/99…

Developed PASC vs Did not

But never V@xxed vs Unv@xxed..

“we used a high throughput systems serology approach to dissect the humoral response to SARS-CoV-2 ...in the serum and cerebrospinal fluid (CSF) from 112 infected individuals who developed or did not develop neuroPASC.”

COVID-19の神経学的後遺症は、過去のコロナウイルスからの免疫学的刷り込み(抗原原罪)によって決定される #neuroPASC
medrxiv.org/content/10.110…

他の一般的なコロナウイルスに対して著しく抗体反応を示した。

抗原原罪がneuroPASC疾患の予後判定マーカーとして提案されている。

Neurologic sequelae of COVID-19 ( #LongCovid / #PASC ) are determined by immunologic imprinting/original antigenic sin, from previous coronaviruses.
An Important recent study revisited because of its implications if confirmed! #updatedvaccines

➡️“Surprisingly, neuroPASC…

Our latest research with Vanna Zachariou sheds light on the neurological impacts of non-infectious #SARS -CoV-2 RNA deposition in the dorsal root ganglia - shedding light on a possible driver of #NeuroPASC . Amazing work by Alex Serafini, PhD and Justin Frere tinyurl.com/neuroPASC

🧠 Science is the main pillar of the American Academy of Neurology #BrainHealth Platform 🙌 🧠 🔬

Dr. Iadecola reminded us how far #science has come & how fast 🌪️ to gain knowledge RE: #SARSCoV2 in increased risk of stroke & #LongCovid ( #NeuroPASC ) 🦠 🧬 🧫

So much exciting science ahead 🚀🚀

“suggest[s] millions of Americans presenting with PVS resembling NeuroPASC were indeed exposed to #SARSCoV2 at the beginning of the pandemic, & they deserve the same access to care and inclusion in research studies as patients with NP with confirmed #COVID19 diagnosis”
#LongCovid

BREAKING: Pre-existing immune responses against related viruses shape the response to current infection, as a key prognostic marker of neuroPASC disease: #ImunologicalImprinting
➡️“A Pathogenic role for compromised anti-SARS-CoV-2 responses in the CSF, likely resulting in…

Overall, study findings point to a pathogenic role for compromised anti-SARS-CoV-2 responses in the CSF, likely resulting in incomplete virus clearance from the brain and persistent neuroinflammation, in the development of #neuroPASC disease. medrxiv.org/content/10.110…

3/ The neuroPASC patients also showed significantly expanded antibody responses to other common #Coronaviruses including 229E, HKU1, NL63 and OC43

4/ The data suggest that in NeuroPASC, immunologic imprinting from other Coronaviruses may induce a defective #antibody -mediated control of SARS-CoV-2 infection, potentially resulting in incomplete or delayed #virus clearance (persistence)

‘neuroPASC showed significantly expanded antibody responses to.. common Coronaviruses, including 229E, HKU1, NL63, & OC43.This biased humoral activation across coronaviruses was particularly enriched in neuroPASC individuals with poor outcome, suggesting.. immunologic imprinting’

2/ Specifically, they found that neuroPASC patients exhibited attenuated systemic antibody responses against #SARS -CoV-2, characterized by decreased capacity to activate antibody-dependent complement deposition, NK cell activation + to bind Fcγ receptors

他の一般的なコロナウイルスへの免疫反応の有意な増強を示した。この偏った液性免疫の活性化は予後不良なneuroPASC患者でより顕著であった。
medrxiv.org/content/10.110…
一般的なコロナウイルスによる免疫学的刷り込みによりSARS-CoV-2への抗体反応が減弱し、neuroPASCにつながっているのではないか、と

'surprisingly, neuroPASC individuals showed significantly expanded antibody responses to other common Coronaviruses, including 229E, HKU1, NL63, and OC43. This (...) was particularly enriched in neuroPASC individuals with poor outcome, suggesting an original antigenic sin'

A new acronym
neuroPASC

neurological Post-Acute Sequelae of COVID-19

'The pathogenesis of neuroPASC is not well understood,hypotheses include SARS-CoV-2-induced immune dysfunctions, hormonal dysregulations,
persistence of SARS-CoV-2 reservoirs'

#wearamask save your brain

#NeuroPASC may be more of a secondary phenomenon from the inflammation that happens in the body and then is ultimately transferred into the central nervous system. re. Natalia Rost, MD, American Academy of Neurology

jamanetwork.com/journals/jama/…
Study➡️n.neurology.org/content/100/17…

Preprint* #LongCovid
'... the neurological manifestations of long COVID could be due to incomplete clearance of the virus from the brain causing neuroinflammation and that immunologic imprinting could be a prognostic marker for neuroPASC.'
news-medical.net/news/20221115/…

Herbert Renz-Polster Jonas R. Kunst (@kunstjonas.bsky.social) NeuroPASC is more than these few serious issues you mention though, right?

More evidence of immune imprinting:

'Surprisingly, neuroPASC showed significantly expanded antibody responses to other common Coronaviruses'

This led to less effective systemic antibody responses against SARS-CoV-2, increasing risk of #viralpersistence

medrxiv.org/content/10.110…