Engineered 3D mini-colons with spatiotemporal control of tumorigenic transformation enable long-term tumorigenesis studies ex vivo, capturing intra- and inter-tumoral diversity and pathophysiology similar to in vivo models. nature.com/articles/s4158… #NBThighlight

Antisense oligonucleotide rescued neuronal defects by suppressing pathogenic CACNA1C exon 8A in Timothy syndrome type 1 patient-derived brain organoids in vitro and upon transplantation into rat brains. nature.com/articles/s4158… #NBThighlight

Pooled multicolor tagging of proteins in live cells for looking at subcellular protein dynamics. bit.ly/3xMNOfD #NBThighlight

DELiVR, is a deep-learning pipeline for whole-brain cell mapping, which is trained on reference annotations generated in a virtual reality environment. nature.com/articles/s4159… #NBThighlight

Certain nuclear RNAs were found persisting for years in mouse brain cells, playing crucial role in maintaining heterochromatin, highlighting the potential of long-lived RNAs for epigenetic regulation and lifelong neural function. science.org/doi/10.1126/sc… #NBThighlight

The anticancer efficacy of CAR T cells is enhanced by overexpression of FOXO1. nature.com/articles/s4158… nature.com/articles/s4158… #NBThighlight

Digital (nano)colloid-enhanced Raman spectroscopy can reliably detect various analytes and target molecules at low concentrations with high sensitivity.
bit.ly/3vWDYaq #NBThighlight

Super-resolution microscopy with RESI increases the spatial resolution to the Ångström scale for all three dimensions. #NBTHighlight nature.com/articles/s4158…

The Spatial Omics DataBase combines a data resource of currently more than 2400 experiments from multiple spatial omics technologies with interactive data analytical modules. #NBThighlight Nature Biotechnology

nature.com/articles/s4159…

A spinal cord neuroprosthesis facilitates walking, improves balance and reduces freezing of gait in a patient with #ParkinsonsDisease via Nature Biotechnology #NBThighlight nature.com/articles/s4159……