Ludwig Harvard Medical School's Zuen Ren, M.D., Ph.D. presented his research at #AACR24 in a poster titled, 'Multiomics analysis unravels tumor metabolic reprogramming and potential resistance mechanism(s) to curative therapy in triple negative breast cancer.'

Now Online In memoriam Judy Campisi: spreading cellular senescence dlvr.it/T5QkmL

Researchers have discovered a type of organelle, a fundamental cellular structure, that can turn nitrogen gas into a form that is useful for cell growth go.nature.com/43XpKmj

PICI-supported nature study: 2022 Parker Bridge Fellow Evan Weber & Penn Medicine, Children's Hospital Stanford Medicine program CAR T cells w/ high FOXO1. Gives stem-cell properties, faster growth & longer survival. Could improve CAR T efficacy across cancers. nature.com/articles/s4158…

1/Time is brain! But what time is it?

If you don’t know the time of stroke onset, are you able to deduce it from imaging?

Here’s a thread to help you date a stroke on MRI!

Ludwig University of Oxford's Joanna C Lima presented research at #AACR24 identifying in mice the early cancerous lesions caused by the loss of a pair of genes—Vhl and Prbm1—whose joint inactivation suffices to initiate a type of renal cancer.

FDA new drug approvals in Q1 2024 bit.ly/3xziIbc
10 new drugs were approved, including first-in-class drugs for NASH/MASH, pulmonary arterial hypertension, Duchenne muscular dystrophy and PNH. Find out more in this new analysis from Paul Verdin Evaluate Pharma

Truly an honor to deliver a keynote talk at the awesome AWSOM workshop! My slides are at drive.google.com/file/d/1opRBX9… which includes our work on scMoMaT, scDisInFact, scHybridNMF and scMultiSim.

Visualizing set relationships: EVenn's comprehensive approach to #Venn diagrams onlinelibrary.wiley.com/doi/full/10.10…
Available at: ehbio.com/test/venn
#Bioinformatics #visualization
Wiley in research Wiley Microbiology

New in The Innovation Geoscience! Multimodal artificial intelligence foundation models Unleashing the power of remote sensing big data in earth observation.
Multimodal AI foundation models represent the future of remote sensing(RS) big data analysis, ready to unleash the…

New in The Innovation Energy! Harvesting energy from the sun and space A versatile collector for simultaneous production of electricity, heat, and cold energy.
Wang et al. proposed and designed an innovative energy collection device capable of simultaneously harnessing solar…

Interesting and flexible new gene regulatory network inference method (LINGER) that uses lifelong neural networks to retain prior knowledge from atlas scale bulk data while fitting new single cell multiome data ⁦Nature Biotechnology⁩ ⁦Zhana Duren⁩ nature.com/articles/s4158…

Exited to share our new paper by Gang Du @ , Liam Liam Healy, Liron David Liron David and others on GSDMD palmitoylation. “ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D” in Nature nature.com/articles/s4158…. Even full-length GSDMD can form pores!

Online Cancer Cell
The crosstalk between macrophages and cancer cells potentiates #PancreaticCancer cachexia
By Min Li & colleagues OU Health Stephenson Cancer Center
cell.com/cancer-cell/fu…

As my lab develops Seurat, I wanted to share some thoughts on the important Seurat and scanpy package selection preprint from Joseph Rich/Lior Pachter 🧵

Synergistic fluorescent hydrogel actuators with selective spatial shape/color-changing behaviors via interfacial supramolecular assembly

doi.org/10.1002/smm2.1…

𝗠𝗶𝗻𝗶𝗺𝗮𝗹𝗹𝘆 𝗜𝗻𝘃𝗮𝘀𝗶𝘃𝗲 𝗔𝗽𝗽𝗿𝗼𝗮𝗰𝗵 𝗶𝗻 𝗘𝗚𝗦: 𝗟𝗮𝗽𝗮𝗿𝗼𝘀𝗰𝗼𝗽𝗶𝗰 𝗗𝗶𝘃𝗶𝘀𝗶𝗼𝗻 𝗼𝗳 𝗕𝗮𝗻𝗱 𝗳𝗼𝗿 𝗔𝗱𝗵𝗲𝘀𝗶𝗼𝗻𝗮𝗹 𝗦𝗺𝗮𝗹𝗹 𝗕𝗼𝘄𝗲𝗹 𝗢𝗯𝘀𝘁𝗿𝘂𝗰𝘁𝗶𝗼𝗻
🔴Previous open appendicectomy via Lanz incision
🔴Presented with CT confirmed…

Online Now! A Novel Integrated Pipeline for #Site -Specific #Quantification of N- #glycosylation . #personalized treatment #prognosis evaluation #IgAN and #Membranous #nephropathy
link.springer.com/article/10.100…

A guide to cell death pathways

#Apoptosis
#Necroptosis
#Pyroptosis
Autophagic/Lysosomal cell death
#Ferroptosis
#Entosis /Cell Cannibalism
#Excitotoxicity /Ion disequilibrium

Inhibiting/Activating specific modes of death to treat human disease

Archived for learning & writing…

💫🌟🔝🔝🔝The Hallmarks of Precancer🌟💫
OncoAlert AACR #AACR24
Cancer Discovery aacrjournals.org/cancerdiscover…
AACR Journals, April 4, 2024

💡 Key Findings:
1️⃣ Importance of Precancer Research: Crucial for effective early interventions. Identifying at-risk tissues and early lesions can…