Happy 2023 everyone!! May you all have many blessings, successes, happiness, and good things. Amen! #NewYear sEve #NewYear #NewYear sResolution #NewYear sRockinEve #NewYear sDay #NewYear s2023 #HappyNewYear #HappyNewYear 2023 #HappyMEWYear2023 #goodbye2022 #goodbye2022 hello2023 #2023

You can help fund research into cures and therapies for GRI Disorders by donating to CureGRIN! Donate today at bit.ly/3tuTuVI

#GRIN1 #GRIN2A #GRIN2B #GRIN2D #GRIA1 #GRIA2 #GRIA3 #GRIA4 #GRIK2
#GRIawareness #GRIDisorder

We’re super proud of Macsen’s progress since November so we’re treating him to a new pop to celebrate every time he invites a new Disney friend

#TeamMacs
#GRIN2a

Omar Danoun, MD Doc, an 11 yr with Pathogenic variant, c.2357-2A>T (Splice acceptor) in GRIN2A what type of medicine should be used instead?

Little man home from hospital- it’s a hard road this palliative care life ❤️ #grin2a

Have a look at our 2022 achievements on #GRIN1 #GRIN2A #GRIN2B #GRIN2D #GRIA1 #GRIA2 #GRIA3 #GRIA4 :
uniklinikum-leipzig.de/einrichtungen/…

Thanks to the research groups of Tim Benke, Steve Traynelis and Dennis Lal

Join our registry grin-portal.broadinstitute.org
CureGRIN GRIN2Bsyndrome

Listen to auto32 - what you need [grin2a] by grin2a on #SoundCloud
soundcloud.com/grin2a/auto32-…

CureGRIN We have down the whole of March is GRIN Awareness Month. We shared this in out most recent podcast. Were we inaccurate on that?

Happy to pop a correction in th3 show notes if so.

podfollow.com/signalise-a-da…

#GRIN1 #GRIN2A #GRIN2B #GRIN2D #GRINawareness #GRINDisorder

5/

...but we can do better than this

...we can comb through medical records of 52K+ individuals

...to see which genetic diagnoses are identified in various speech disorders

...we find known associations for #STXBP1 (not communicating verbally) and #GRIN2A (speech apraxia)

Out of 1320 nsSNPs retrieved from the NCBI database, initially 16 were predicted as deleterious by 9 tools. Further assessment & Molecular Dynamic Simulation revealed that the variant I463S is likely to be the most deleterious in GRIN2A-associated diseases
journals.plos.org/plosone/articl…

We investigate potentially recognisable features of  #GRIDisorder  with a facial recognition tool.
#GRIN1 #GRIN2A #GRIN2B #GRIN2D #GRIA1 #GRIA2 #GRIA3 #GRIA4
You can support our research with a photograph. 
This is how: uniklinikum-leipzig.de/einrichtungen/…
CureGRIN GRIN2Bsyndrome
Thanks you!

'[...]in schizophrenia, but the SCHEMA study provides the first solid genetic evidence of this. Additionally, GRIN2A activity in the brain peaks during adolescence, around the time people suffering schizophrenia begin to experience symptoms.[...]'

MECP2 and TSC2 were the most frequent genes identified; GRIN2A and SCN1B
were the second most common genes.

#scn1b #grin2a #seizures #epilepsy

GRIN Disorder is part of a more prominent family of related to ionotropic glutamate receptors and is caused by a change in 1 of 7 GRIN genes: GRIN1, GRIN2A, GRIN2B, and GRIN2D. These genes code are essential for learning and memory. Learn more here at: curegrin.org/resources/

Lisa 💙 Just looked up grin2A online what a shocking and rare condition, sending love and prayers to you and your family through the interweb

'[...]Insights into two of the 10 genes from the SCHEMA study, GRIN2A and GRIA3, further implicate the synapse as a key part of schizophrenia's mechanistic roots[...]

#family #wife #husband
miahcombat.com/collection/fam…

Children with Early-Onset Psychosis Have Increased Burden of Rare GRIN2A Variants dlvr.it/SnCzJ5

Ken Myers Brain Fascinating. I was just teaching our fellows today about potential role of Memantine in DEEs, especially GRIN2A.

For those with a wicked sense of humor!

Meet Ben!

Read about Ben at curegrin.org/ben

#GRIN1 , #GRIN2A , #GRIN2B , #GRIN2D #GRIawareness #GRIdisorder #GRIA1 #GRIA2 #GRIA3 #GRIA4 #GRIK2

Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show EEG abnormalities in common with schizophrenia patients dlvr.it/SlRNKN

Meet Sofia!

Read about Sofia at curegrin.org/sofia

#GRIN1 , #GRIN2A , #GRIN2B , #GRIN2D #GRIawareness #GRIdisorder #GRIA1 #GRIA2 #GRIA3 #GRIA4 #GRIK2

Research opportunity for #GRIN1 #GRIN2A #GRIN2B #GRIN2D #GRIA1 #GRIA2 #GRIA3 #GRIA4 families!