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So proud of Davide Seruggia my once former PhD student at Centro Nacional de Biotecnología (CSIC) and then postdoc in US and then PI in Vienna funded by European Research Council (ERC) now describing #CRISPR CLEAR, a new system using evolved base editors to functionally disect DNA Regulatory Elements, such as #enhancers at bp level

In this new preprint, we do a deep dive into the temporal relationship between DNA #methylation, #chromatin and #enhancers. Amazing work by first author Lindsey Guerin and thanks to our collaborators Ihrie Lab, Ken Lau Lab, & biomodal. biorxiv.org/content/10.110…

#Schools2030 We welcome all our #Partners, #collaborators, #wellwishers, #enhancers,#CommunityMobilizers and #beneficiaries to join us in this transformative journey. Together we embrace Community ownership and leadership.

These regions act as cryptic #enhancers 🕵️ (i.e., usually not active in mESCs) and constructing a gene regulatory network (🙌 Judith Zaugg, Daria) we identify putative target genes, specifically upregulated in K9A mESCs. Immune and developmental (bivalent) genes are included!

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estimated #enhancers of digital (and human) #transformationI wish you a great weekend❤️! #SFO GroWrk Remote Wellbeing Solutions - Synctrics Synctrics - Making Team Meetings Work! AlphaSights @TPWGiveBetter Shannon Farley Jono Bacon (#BayArea #Oakland Boom Factor Net Impact Felt #CX #h2h #CRM #CxGis #PR #FF

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