Some people might read this and think, that's just not my world, I am stuck in this world where software breaks all the time and everything I build is disposable. Even if that is kind of the case for you, there is still good news, because this isn't an all-or-nothing problem.

my R01 is cancelled lol meanwhile liz holmes AND the crispr baby guy are raising millions I'm going to become the Joker

guardrails at home: just reminding people that innstructor's semantic validation capabilities, we have a powerful way to validate structured outputs against sophisticated criteria. python.useinstructor.com/blog/2025/05/2…

Why don't Harvard/Stanford just raid their endowments to cover Trump’s research funding cuts? Take Harvard as a case study. They have a $53B endowment. That's massive! Harvard’s endowment pays out ~5% a year. That’s ~$2.6B in 2025. Covering the $3B shortfall from Trump's cuts is

We have two awesome new videos on MLX at #WWDC25 this year. - Learn all about MLX. - Learn all about running LLMs locally with MLX. Angelos Katharopoulos, Shashank Prasanna, myself, and others worked super hard to make these. Check them out and hope you find them useful!

Machine learning theory and practice 😀

William Shatner I designed the patch for Marvin Rush, Star Trek: TNG's director of photography. He had the vests made as cast-and-crew gifts from the camera department (the "interplanetary imaging team.")

9/ In vitro is clean. In vivo is messy. The bloodstream doesn’t care about your figure 3 volcano plot.

“If things continue as they are, American science is ruined.” Make no mistake, the collapse isn’t theoretical - it’s happening. Top talent no longer sees the US as a viable option, they are instead choosing Austria, Japan & Germany. This damage will take decades to recover from.

Excited to share the pre-print we’ve been working on for the last ~4 months: “Distillation of atomistic foundation models across architectures and chemical domains” Deep dive thread below! 🤿🧵

I feel seen

My lab’s 5-year NIH R01 grant, awarded to study gene therapy for hearing loss, was abruptly terminated. I want to share how this action has been incredibly harmful and disruptive, not just to my lab, but to the scientific process itself. 1/15

I tried... 😅

🧬Introducing La‑Proteina: a partially‑latent flow‑matching model that co‑generates sequence + all‑atom structure for proteins up to 800 aa 🧬 Side‑chains live in latents, backbone explicit → 75 % codesign & SOTA motif scaffolds 🔥

1/ It's time to bring back "designed in California, made in California.” Today, at REINDUSTRIALIZE SUMMIT, Ashlee Vance and I introduced Solano Foundry, the largest advanced manufacturing park in America, an hour north of Silicon Valley. Built by California Forever with JLL. 🧵

As you know I'm obsessed with power laws in biology, which is a biological consequence of fundamental principles, like energy conservation from the first law of thermodynamics. Geoffrey West showed how highly optimized biological networks—think blood vessels or respiratory

Data from the second human treated with a prime edited medicine: a 56-year-old male with chronic granulotamous disease (CGD) had his bone marrow prime edited to insert the missing GT in NCF1, restoring NADPH oxidase function in neutrophils (DHR positivity) several fold beyond the

The high-throughput magnetic IgG purifier is complete. Our tech transfer encouraged me to patent it, but I follow Jonas Salk's example and make a gift to humankind. You can make it with this plan a360.co/43naWNT or I will make you one at zero-profit cost

Not to add to the discourse, but… It’s ‘toe the line,’ not ‘tow the line.’ It’s ‘free rein,’ and not ‘free reign.’ It’s ‘eke out,’ not ‘eek out.’ It’s ‘sleight of hand,’ not ‘slight of hand.’ It's ‘Anchors aweigh,’ and not ‘Anchor's away!’

Terence Tao: "This is not a routine policy shift - it is a deliberate dismantling of the institutions, funding, and freedoms that have sustained American science for generations."