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Did you know that 28 out of 34 signalling pathways, and ~60% of the proteome, respond differently depending on the metal ion environment? Neither did we, but now believe that the metal ion levels are one of the big "known unknowns" in cellular networks biorxiv.org/content/10.110…

Researchers have found the oldest known sex chromosome in animals — the octopus Z chromosome — which first evolved in an ancient ancestor of octopuses around 380 million years ago go.nature.com/3uUMFSe

A paper in nature suggests that bumblebees can teach others new behaviours too complex for them to learn alone. In the study, a bee taught to solve a puzzle for a sugary reward can go on to train other bees to complete the task. go.nature.com/49Fbxwp

Happy to post this study on a new method for tryptophan labeling and its use to identify cation-pi interactions led by Xiao Shaw Xie and Patrick with Toste Group College of Chemistry UC Berkeley MCB in nature ! nature.com/articles/s4158… 1/n

Great work on the different clusters of type 2 diabetes-associated variants and how they differ in terms of disease mechanisms, tissue and cell types of action, and ancestry-specific T2D genetics. It is well known that fat distribution differs across ancestries and this

Very excited to share our recent discovery of a novel taurine metabolism pathway! We identified the orphan enzyme PTER as the predominant taurine N-acetyltransferase/hydrolase that regulates energy balance Long Lab biorxiv.org/content/10.110…

I am excited to share our preprint: “A torpor-like state in mice (TLS) slows blood epigenetic aging and prolongs healthspan”. Congratulations to Lorna Jayne and big thanks to our collaborators Prof Steve Horvath, Vijay Sankaran, Vadim Gladyshev and others. biorxiv.org/content/10.110…

Excited to share our latest work revealing the requirements of pyrimidine nucleotides in the control of glucose oxidation and lipogenesis published in Science Magazine. Huge congratulations to co-first authors Umakant Sahu and Elodie Villa! science.org/doi/10.1126/sc…

#MysterySolved! Krönke &co show nature that glucocorticoids are anti-inflammatory not in a transcriptional manner (🤯), but by boosting the Krebs cycle in macrophages, driving excessive #itaconate that interferes with pro-inflammatory cytokine induction! Doi.org/10.1038/s41586…

Synthetic G protein-coupled receptors for programmable sensing and control of cell behavior biorxiv.org/cgi/content/sh… #bioRxiv

🎉 Drumroll, please! Meet the 2024 #PDSoros Fellows! 🗽 Selected from 2,300+ applicants, these 30 exceptional graduate students are changing the game in their respective fields. Click the link to get to know these trailblazers! #ImmigrantExcellence 🎓🎉 pdsoros.org/meet-the-class…

In nature today, we reported that adhesive implant-tissue interfaces can prevent the formation of observable fibrous capsules on various organs, including the abdominal wall, colon, stomach, lung and heart, in diverse animal models, including rats, mice, humanized mice and pigs.

We thought there wasn't much new to learn about the cell cycle. Turns out we were wrong! Our paper (out today nature) identifies a novel alternative cell cycle that regulates differentiation, not cell division. tinyurl.com/4a6yeuke. 1/10

Drugs like Ozempic are great for weight loss, but they make some people feel sick. We discovered that the brain circuits mediating the appetite suppression are distinct from those that mediate nausea – a finding that may be leveraged to develop more selective GLP1-based drugs.

Cool discovery about 🦇 antibodies: temperature fluctuations regulate antigen binding strength and diversity doi.org/10.1038/s41467…

Our latest out today nature! We revisit a century-old theory and show that metabolic gradients work hand-in-hand with genetic&signalling instructions to shape the embryo. Glucose isn't just an energy source, it acts as a major conductor of the body plan🍬 nature.com/articles/s4158…

Our new paper, "NK2R control of energy expenditure and feeding to treat metabolic diseases," is out today in nature. Here we identify a single receptor that can both peripherally increase energy expenditure and centrally suppress appetite. nature.com/articles/s4158… 1/12 🧵👇

Nature research paper: Adipose tissue retains an epigenetic memory of obesity after weight loss go.nature.com/4eJizC8

The outer ear is a mammalian innovation but where did it come from? In our study in nature, Mathi Thiruppathy and colleagues find that the outer ear arose from modification of an ancestral gill program first originating in marine invertebrates. nature.com/articles/s4158… 1/n

Thrilled to share that my work is out in nature. Here, we introduce Peptide Predictor, a tool for identifying new bioactive peptides. Using this method, we discovered BRP, an anti-obesity peptide. Huge thanks to the SvenssonLab and all our collaborators! nature.com/articles/s4158…