Pathology myths debunked!

Throwback to this case from a few years ago. Check out this bone marrow core biopsy and let's discuss what's going on. Remember to always look beyond the marrow cells (marrow space) What could cause this change?

ALK-positive ALCL-"small cell variant": ➡️Very deceptive morphology (NOT anaplastic-looking) can be easily missed ➡️Leukemic presentation is common #hemepath #lymsm #PathTwitter #MedTwitter

Nodal TFH cell lymphoma, follicular-type➡️ If a lymph node looks like it's involved by NLPHL or FL, but the aberrant population has a T-cell phenotype, think about this entity #hemepath #lymsm #PathTwitter #medtwitter

CLL with trans-differentiation to histiocytic sarcoma… WILD 🤯 Makes you wonder… why do the neturophils love these tumor cells so much (or is it the other way around 🤔) #hemepath #lymsm

Not great pictures but still worth sharing with #Pathtwitter 65 Y with AUB. EMB showed side by side serous carcinoma and microglandular hyperplasia-like endometrioid adenocarcinoma! IHCs are p53 and Ki67 #Gynpath

There's atypical plasma cells, and then this guy.

High grade B cell lymphoma, bone marrow infiltration. Those chromosomes want to escape! #cytopath #hemepath

#hemepath Relapsing fever - Borrelia recurrentsis

We proudly welcomed L. Jeffrey Medeiros, MD, Chair, Dept. of #Hematopathology at MD Anderson Cancer Center, as our #Pathology Grand Rounds speaker. Dr. Medeiros spoke on “Diffuse Large B-Cell Lymphoma.” Here, Dr. Medeiros is w/his host, Po-Han Chen, MD, PhD, Instructor of Pathology Yale School of Medicine.

a retired pathologist’s name— whom I haven’t thought of in a while but who practiced for many years written on a slide tray today. once upon a time he was waiting for levels, or had important IHCs whatever it was that day —now it’s just a tray. #pathtwitter #medtwitter

"Wondering who can be more dysplastic than me" -- the mega.

To complete the story, here are the characteristic slender Auer rods and cytoplasmic granules. Yes, this is AML t(8;21)!

I bet pathology conferences have competitions for finding things on a slide. Like first person who finds a Howell-Jolly body wins and when somebody finds it the whole auditorium cheers, but then the referee comes in and is like no thats a Pappenheimer body & they get disqualified

I didn`t start my academic career until I was 30. I didn`t obtain my PhD until I was 35. At 20, I thought my life was over🎗️ At 42, I know it`s just the beginning & I signed the contract for my permanent position (tenure track/ assistant professor). It is never too late to start.

A nice example of splenic B-cell lymphoma/leukemia with prominent nucleoli, aka hairy cell leukemia-variant

I couldn't resist... hey, ChatGPT, make me an image of a #medical student happy to have found the field of #pathology/1

Granular Mott cells in multiple myeloma |American Journal of Hematology | Blood Research Journal | Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/aj…

Doing a manual differential count in CLL.